Surgical Neuropathology Service

We offer state of the art diagnostic services and provide timely consultations in all areas of neuropathology, including neoplastic, infectious, inflammatory/demyelinating, vascular, and developmental diseases.  Our histologic analysis is supported by the latest specialized immunohistochemical stains (see list below) and comprehensive molecular testing for CNS tumors.

CNS tumors

Gliomas including astrocytoma, oligodendroglioma, and ependymoma
Neuronal and glioneuronal tumors
Medulloblastoma and other embryonal tumors
Meningioma, solitary fibrous tumor, and other intracranial sarcomas
Peripheral nerve sheath tumors including neurofibroma, schwannoma, and MPNST
Pituitary adenomas (pituitary neuroendocrine tumors/PitNETs) and other pituitary neoplasms
Intracranial lymphoma and histiocytosis
Metastatic disease

Infectious and inflammatory diseases

Demyelinating diseases including multiple sclerosis
Autoimmune encephalitis and vasculitis
Meningitis and encephalitis due to viral, bacterial, and fungal organisms

Epilepsy and developmental neuropathology

Focal cortical dysplasia and tuberous sclerosis
Hippocampal sclerosis
Epilepsy-associated low-grade neuroepithelial tumors
Leukodystrophies and other genetic disorders

Specialized immunohistochemical stains available

• Glial markers:  GFAP, OLIG2, SOX10, MAP2, EMA, D2-40, CD99
• Neuronal markers:  Synaptophysin, Neurofilament, NeuN, MAP2
• Balloon cell markers: Alpha B crystallin, CD34
• Glioma mutant protein specific antibodies:  IDH1 R132H, Histone H3 K27M, Histone H3.3 G34R/V, BRAF V600E
• Additional glioma molecular subtyping:  ATRX, p53, p16, CD34, BCOR
• Ependymoma molecular subtyping:  L1CAM, Histone H3 trimethylated lysine 27 (H3K27me3)
• CNS embryonal tumor subtyping:  INI1/SMARCB1/BAF47, BRG1/SMARCA4, LIN28A, BCOR
• Medulloblastoma molecular subtyping:  Beta-catenin, ALK, LEF1, YAP1, GAB1, p53
• Meningioma and solitary fibrous tumor markers:  EMA, SSTR2A, BAP1, H3K27me3, STAT6
• Pituitary tumor subtyping:  PIT1, TPIT, SF1, HGH, Prolactin, ACTH, TSH, CAM 5.2, ER, GATA3, Antimitochondrial antigen (AMA), TTF1 
• Peripheral nerve sheath tumor evaluation:  S-100, SOX10, INI1/SMARCB1/BAF47, p16, H3K27me3
• Infection organism antibodies:  Herpes simplex virus-1/2, VZV, CMV, Polyoma (including JC virus), Toxoplasma gondii, T. pallidum