Biswarathan Ramani, MD, PhD

Clinical Instructor
Pathology

UCSF
Pathology, Box 0102
1651 4th Street, Room 471A
San Francisco, CA 94143
United States

UCSF Directory

Research and Clinical Interests

My research interests have been focused on understand factors regulating protein misfolding and aggregation in neurodegenerative diseases. I apply cutting-edge CRISPR functional genomics techniques, microscopy, and biochemical tools on cell-based models and animal models of disease to interrogate neuronal protein homeostasis pathways.

Selected Publications
  • Ramani B, Rose IVL, Pan A, Tian R, Ma K, Palop JJ, Kampmann M. Scalable, cell type-selective, AAV-based in vivo CRISPR screening in the mouse brain. bioRxiv [Preprint]. 2023 Jun 27:2023.06.13.544831. doi: 10.1101/2023.06.13.544831. PMID: 37398301; PMCID: PMC10312723.
  • Ramani B, Gupta R, Wu J, Barreto J, Bollen AW, Tihan T, Mummaneni PV, Ames C, Clark A, Oberheim Bush NA, Butowski N, Phillips D, King BE, Bator SM, Treynor EC, Zherebitskiy V, Quinn PS, Walker JB, Pekmezci M, Sullivan DV, Hofmann JW, Sloan EA, M Chang S, Berger MS, Solomon DA, Perry A. The immunohistochemical, DNA methylation, and chromosomal copy number profile of cauda equina paraganglioma is distinct from extra-spinal paraganglioma. Acta Neuropathol. 2020 Dec;140(6):907-917. doi: 10.1007/s00401-020-02221-y. Epub 2020 Sep 6. PMID: 32892244; PMCID: PMC7682537.
  • Solomon DA, Ramani B, Eiger-Moscovich M, Milman T, Uludag G, Crawford JB, Phan I, Char DH, Shields CL, Eagle RC Jr, Bastian BC, Bloomer MM, Pekmezci M. Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations. Ophthalmology. 2022 Dec;129(12):1429-1439. doi: 10.1016/j.ophtha.2022.07.002. Epub 2022 Jul 12. PMID: 35835335.
  • Ramani B, Panwar B, Moore LR, Wang B, Huang R, Guan Y, Paulson HL. Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes. Hum Mol Genet. 2017 Sep 1;26(17):3362-3374. doi: 10.1093/hmg/ddx224. PMID: 28854700; PMCID: PMC5886175.
  • Ramani B, Harris GM, Huang R, Seki T, Murphy GG, Costa Mdo C, Fischer S, Saunders TL, Xia G, McEachin RC, Paulson HL. A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript. Hum Mol Genet. 2015 Mar 1;24(5):1211-24. doi: 10.1093/hmg/ddu532. Epub 2014 Oct 15. Erratum in: Hum Mol Genet. 2017 Aug 15;26(16):3232-3233. PMID: 25320121; PMCID: PMC4321438.