Gastrointestinal & Hepatobiliary Pathology Fellowship Abstracts

KW Wen, G Kim, P Rabinovitch, D Wang, A Mattis, WT Choi. Diagnosis, Risk Stratification, and Management of Ampullary Dysplasia by DNA Flow Cytometric Analysis of Paraffin Embedded Tissue.

A Blank, N Joseph, R Gill, S Kakar. LFABP-Negative Hepatocellular Adenoma: Spectrum of Morphologic and Molecular Characteristics with Emphasis on Atypical Features.

S Umetsu, N Joseph, SJ Cho, D Jain, V Deshpande, S Kakar. Focal Nodular Hyperplasia-like Nodules Arising in the Setting of Hepatic Chronic Vascular Disorders Show Beta-catenin Activation.

C Behling, C Guy, D Allende, M Yeh, O Cummings, R Gill, D Carpenter, P Belth, M Van Natta, M Contos, D Kleiner. Bile Ductular and Portal Pathology in Fatty Liver Disease. N. Patel, D. Leffler, A. Atsawarungruangkit, L. Elli, A. Del Gobbo, M. Salomao, R. Pai, M. Vieth, B.Melcher, J. Hart, A. Olivas, B. Naini, C. Meyerson, WT. Choi, S. Kakar, M. Westerhoff, J. Cheng, P. Gopal, M. Bronner, MM. Prats, M. Robert Persistent Duodenal Mucosal Injury is Common in Follow Up Biopsies from Celiac Disease Patients Despite Strict Adherence to a Gluten Free Diet and Decreases in Anti-IgA Tissue Transglutaminase (tTG) Levels.

KW. Wen, S. Umetsu, J. Goldblum, R. Gill, G. Kim, N. Joseph, P. Rabinovitch, S. Kakar, G. Lauwers, WT. Choi. DNA Flow Cytometric and Interobserver Study of “Crypt Cell Atypia” in Inflammatory Bowel Disease.

M. Reid, Y. Xue, S. Balci, B. Pehlivanoglu, I. E. Seven, T. Taijiri, N. Ohike, K. Jang, G. Kim, J. Sarmiento, D. Kooby, S. Maithel, N. V. Adasay. Histologic Types of Ampullary Carcinoma: Frequency and Clinicopathologic Associations in 367 Cases.

WT. Choi, M. Yozu, G. Miller, A. Shih, J. Misdraji, G. Lauwers. A Multicenter Clinicopathologic Study of “NonConventional” Dysplasia in Patients with Inflammatory Bowel Disease.

D. Balitzer, T. Saunders, B. Molden, S. Kakar, R. Gill. BRAF V600E and BAP1 immunohistochemistry aids in distinction between bile duct adenoma and intrahepatic cholangiocarcinoma.

KW. Wen, A. Srivastava, N. Joseph, T. Saunders, S. Kakar. “Sex Cord-Like” Hepatic Carcinoma: a Rare Variant of Intrahepatic Cholangiocarcinoma? 

S. Kirimlioglu, L. Bull, N. Joseph, S. Kakar, K. Bove, L. Ferrell, U. Ince, G. Kim. Hepatocellular carcinoma in patients with MDR3 deficiency.

D. R. Fels Elliot, M. Tavakol, B. Hameed, L. Ferrell, S. Kakar, R. Gill. Evaluation of Clinicopathologic Presentation and Outcomes in Parenchymal Rejection Versus Acute Cellular Rejection in Liver Transplant Biopsies. 

D. Balitzer, S. Umetsu.Evaluation of HCC in Setting of Direct-Acting Antiviral Therapy. 

KW Wen, PS Rabinovitch, D Huang, AN Mattis, W-T Choi.  Indefinite for Dysplasia” in Inflammatory Bowel Disease: Aneuploidy as a Diagnostic and Prognostic Marker of High-Grade Dysplasia or Colorectal Cancer

D Balitzer, NM Joseph, LD Ferrell, D Jain, X Zhang, N Shafizadeh, S Kakar. Immunohistochemical and Molecular Findings in Cholangiolocellular Carcinoma are Similar to Well-Differentiated Intrahepatic Cholangiocarcinoma.

D E Kleiner, A Sanyal, M Van Natta, P H Belt, D Allende, E Brunt, D Carpenter, M Contos, O Cummings,  RM Gill, C Guy, MM Yeh, L Wilson, C A Behling. Patterns of Fibrosis Progression and Regression in Steatohepatitis.

NM Joseph, E Brunt, E C Marginean, I Nalbantoglu, S Thung, MM Yeh, SE Umetsu, LD Ferrell, DC Snover, RM Gill.  Recurrent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasms.

R Fels Elliott, L D Ferrell, B Hameed, S Kakar, RM Gill. Parenchymal Rejection in Liver Transplant Biopsies:  A Form of Rejection Distinct from Severe Acute Cellular Rejection.

B Molden, NM Joseph, D Mattis, A Mattis, S Kakar.  Use of Mutational Analysis and BAP1 Immunohistochemistry for Diagnosis of Intrahepatic Cholangiocarcinoma.

D Roberts, S Kakar, RM Gill. P53 Immunohistochemistry in Hepatocellular Carcinoma Correlates with Recurrent Disease Following Liver Transplantation.

J Anderson, SE Umetsu, M Pekmezci, S Kakar, L Wang.  Morphologic Features Predictive of Invasive Adenocarcinoma in Colonic Endoscopic Biopsies in the Absence of Definite Stromal Desmoplasia.

KW Wen, PS Rabinovitch, D Huang, AN Mattis, GY Lauwers, W-T Choi. DNA Flow Cytometric Analysis of Gastric Epithelial Dysplasia: Association of DNA Content Abnormality in Gastric Dysplasia with Development of High-Grade Dysplasia and Gastric Adenocarcinoma.

W-T Choi, KW Wen, PS Rabinovitch, D Huang, AN Mattis, RM Gill.  DNA Flow Cytometric Analysis and Outcomes of Serrated Lesions in Inflammatory Bowel Disease.

C Bowman, J Cohen, S Kakar, SE Umetsu, Z Laszik.  Immunological and Cancer-related Genes Differentiate Between Hepatocellular Adenoma and Well-differentiated Hepatocellular Carcinoma.

D Balitzer, LD Ferrell, M Peters, S Kakar. Comparison of Clinicopathologic Features of Plasma Cell Hepatitis and Recurrent Autoimmune Hepatitis.

S-Y Liu, H Braun, B Hameed, J Roberts, LD Ferrell, SE Umetsu.  Histopathology of Small-for-Size Syndrome after Living Donor Transplantation.

D Balitzer, J Huei Tsai, RM Gill. Comparison of Clinicopathologic Features Between Recurrent and De Novo Post-Transplant Non-Alcoholic Steatohepatitis.

D Mattis, T Su, A Mattis.  CENP-A Immunohistochemistry Distinguishes Low Copy Number Alterations in Klatskin Tumors Versus Intrahepatic and Extrahepatic Cholangiocarcinomas.

DM Mattis, NM Joseph, I Yeh, E Talevich, C Onodera, AN Mattis. Deep Sequencing of Intrahepatic Cholangiocarcinoma, Extrahepatic Cholangiocarcinoma and Klatskin Tumors.

KW Wen, JP Grenert, NM Joseph, N Shafizadeh, A Huang, M Hosseini, S Kakar. Genomic Landscape in Appendiceal Goblet Cell Carcinoid: Distinct Profile Compared to Neuroendocrine Tumor and Colorectal Adenocarcinoma.

S-Y Liu, G Lauwers, GE Kim, Z Laszik.  Integration of Whole Slide Digital Imaging (WSDI) for Primary Diagnosis: A Validation of Its Utility in Gastrointestinal Pathology Biopsy Workflow at a Multi-Center Academic Institution.

W-T Choi, PS Rabinovitch, T Small, D Huang, AN Mattis, S Kakar. DNA Flow Cytometric Analysis of Barrett's Esophagus-Related Dysplasia Using Paraffin-Embedded Tissue:  DNA Content Abnormality Can Serve as Both Diagnostic Marker of Dysplasia and Predictive Marker of Neoplastic Progression.

D Roberts, S Kakar, RM Gill. A Point-Based Grading System for Hepatocellular Carcinoma Shows Improved Interobserver Agreement and Better Identifies Histologic Features Associated with Recurrent Disease After Liver Transplant.

J Cohen, S Umetsu, S Kakar, Z Laszik. Various Oncogenic Pathways Are Associated with Distinct Immune and Cancer Gene Signatures in Inflammatory and HNF1aInactivated Hepatic Adenomas.

NM Joseph, L Ferrell, S Kakar. Atypical Hepatocellular Neoplasms: Mutational Profile and Copy Number Alterations.

DR Fels Elliott, J Perner, MF Symmons, B Verstak, X Li, M Eldridge, L Bower, M O’Donovan, NJ Gay, OCCAMS Consortium, RC Fitzgerald. Impact of Mutations in Toll-like Receptor Pathway Genes on Oesophageal Carcinogenesis.

W-T Choi, I Brown, T Ushiku, M Yozu, N Setia, A Srivastava, M Johncilla, RK Pai, M Fukayama, J Misdraji, GY Lauwers. Gastric Pyloric Gland Adenoma: A Multicenter Clinicopathologic Study of 65 Cases.

NM Joseph, EM Brunt, C Marginean, I Nalbantoglu, DC Snover, SN Thung, MM Yeh, L Ferrell, RM Gill.  Cancer Gene Sequencing of Hepatic Small Vessel Neoplasm (HSVN) and Hepatic Cavernous Hemangioma.

Y Li, S Prakash, P Treseler, RM Gill.  Clinicopathologic Features of Hepatic Lymphoma, a Large Retrospective Study.

J-H Tsai, PS Rabinovitch, T Small, D Huang, AN Mattis, S Kakar, W-T Choi. Aneuploidy Detected by DNA Flow Cytometry Using Paraffin-Embedded Tissue Can Serve as Both Diagnostic Marker of Dysplasia and Predictive Marker of Neoplastic Progression in Inflammatory Bowel Disease.

L Wang, D Jain, N Shafizadeh, S Kakar. Combined Hepatocellular –Cholangiocarcinoma With Stem Cell Features: Pitfalls In Diagnosis.

Z Yan, X Chen, S Kakar. Hepatic Epithelioid Angiomyolipoma:  Immunohistochemical Pitfalls in Diagnosis.

KW Wen, RM Gill. Immature B-cells Can Be Detected in a Subset of Adult and Pediatric Liver Biopsies: A Potential Pitfall in the Diagnosis of B Lymphoblastic Leukemia/ Lymphoma.

S-Y Liu, S Kakar. Tumor Deposits and Venous Invasion in Colorectal Cancer: Clarification of Morphologic Criteria and Role of These Parameters in Staging.

DE Roberts, S Kakar, RM Gill. Liver Transplantation in the Setting of Hepatocellular Carcinoma: Role of Tumor Differentiation in Predicting the Risk of Recurrence.

S Umetsu, N Shafizadeh, S Kakar: Mucinous Neoplasms of the Appendix: Challenges in Grading and Staging with Proposal for a New System.

D Balitzer, S Kakar. Combined Use of Copper Stain and CK7 Immunohistochemistry for Diagnosis of Cholestatic Liver Disease.

W-T Choi, K-Y Jen, D Wang, RM Gill. Histologic and Clinical Outcomes after Transplantation of Donor Livers with Small Versus Large Droplet Macrovesicular Steatosis.

KW Wen, G Hale, N Shafizadeh, A Huang, M Hosseini, S Kakar. Appendiceal Goblet Cell Carcinoid: Common Errors in Staging and Clinical Interpretation with a Proposal for an Improved Terminology.

C Sangokoya, A Mattis, R Ramachandran, J. Baron. Hepatic Iron Homeostasis: Immunolocalization of Iron Regulatory Factors in Human Liver.

C Tsokos, X Liu, D Solomon, X Chen, G Hale, E Seeley, S Kakar, G Krings. Telomerase Reverse Transcriptase Promoter Mutations (mTERTp) in Combined Hepatocellular(HCC)-Cholangiocarcinoma(CC; cHCCCC) Support Clonal and HCC-Like Origin for Both Components.

G Hale, G Kim, L Ferrell, S Kakar. Glutamine Synthetase IHC in Hepatocellular Lesions: Spectrum of Staining Patterns and Interpretation Concordance.

G Hale, X Liu, X Chen, R Gill, C Tsokos, G Krings, S Kakar: Correlation of ß-Catenin Exon 3 Mutations With Glutamine Synthetase Staining Patterns in Hepatocellular Carcinoma.

E Waterhouse, N Joseph, F Yilmaz, D Nart, K Evason, G Kim, S Kakar, L Ferrell, R Gill, D Solomon. Validation of an RT-PCR assay for detection of recurrent DNAJB1-PRKACA fusion transcripts in fibrolamellar hepatocellular carcinoma.

D Balitzer, N Shafizadeh, N Alshak, S Kakar. Autoimmune Hepatitis: Review of Validity of Histologic Features Included in the Simplified Criteria Proposed By the International Autoimmune Hepatitis Group (IAIHG).

Z Yan, M Torbenson, C Corvera, D Jain, T-T Wu, M Yeh, S Kakar. Fibrolamellar Carcinoma: Proposal for a New Staging System.

C Sangokoya, A Mattis, R Ramachandran, J Baron. MicroRNA In Situ Hybridization Analysis of MiR-485-3p and MiR-122 Expression in Human Liver Development and Disease.

B Buelow, T Amancio, E Brunt, T-C Lu, G Jacobs, H Makhlouf, C Martginean, I Nalbantoglu, C Sempoux, D Snover, S Thung, M Yeh, L Ferrell, R Gill. C-MYC Over-Expression Is Rare in Hepatic Small Vessel Hemangioma and Diffuse C-Myc Staining Is Restricted To Hepatic Angiosarcoma.

Hosseini M, Shafizadeh N, and Kakar S. Evaluation of pT3 vs pT4 Stage and Radial Margin in Colorectal Cancer: Pitfalls in Interpretation and Correlation with Outcome, United States and Canadian Academy of Pathology, 2014 (poster)

Zhao L, Hart J, Hosseini M, and Ferrell L. Segmental Cholangiectasia Clinically Worrisome for Intrahepatic Cholangiocarcinoma: Comparison with Recurrent Pyogenic Cholangitis (RPC), United States and Canadian Academy of Pathology, 2014 (poster)

Sangokoya C, Mattis A, Ramachandran R, and Haron J. Expression of the Iron-regulating MicroRNA miR-485-3p in Hepatic Cirrhosis., United States and Canadian Academy of Pathology, 2014 (poster)

Genrich G, Joseph N, Kim G, Evason K and Kakar S. Relationship of β-Catenin Activation and MYC in Hepatocellular Adenoma and Hepatocellular Carcinoma and hepatoblastoma, United States and Canadian Academy of Pathology, 2014 (poster)

Genrich G, Shafizadeh N, Ferrell L, and Kakar S. Authors Who Are Pathologists-in-Training: Hepatocellular Adenomas in a Large Community Population 2000-2010: Reclassification per Current WHO Classification and Long-Term Follow-Up. United States and Canadian Academy of Pathology, 2013 (poster)

Nguyen T, Torbenson M, Wu T-T, Jain D, Yeh M, Shafizadeh N, and Kakar S. Morphologic and Immunohistochemical Features of Sarcomatoid Hepatocellular Carcinoma, United States and Canadian Academy of Pathology, 2013 (poster)

Cho S-J, Ferrell L, and Gill RM. Expression of Liver Fatty Acid Binding Protein (LFABP) in Hepatocellular Carcinomas, United States and Canadian Academy of Pathology, 2013 (poster)

Krings G, Meyden B, and L Ferrell. Altered Hepatic Vascular and Lobular Organization near Centrizonal Scars in Chronic Venous Outflow Obstruction, United States and Canadian Academy of Pathology, 2013 (poster)

Nguyen T, Phillips D, and Kakar S. Utility of Bile Salt Export Pump Transporter Immunohistochemistry Compared to Other Hepatocellular Markers for the Diagnosis of Hepatocellular Carcinoma, United States and Canadian Academy of Pathology, 2013 (poster)

Can B, Krings G, and Ferrell L. Arterialization and Ductular Metaplasia of Centrizonal Scars in Chronic Venous Outflow Obstruction: A Frequently Misinterpreted Lesion. United States and Canadian Academy of Pathology, 2012 (poster)

Gill R, Alves V, Makhlouf H, Sempoux C, Thung S, and Ferrell L. Small Vessel Hepatic Hemangioma, an Atypical Hemangioma Variant in Adult Liver. United States and Canadian Academy of Pathology, 2012 (poster)

Krings G, Ferrell L, and Gill R. Ki−67 and p53 Expression as an Immunohistochemical Tool in the Differential Diagnosis of Benign and Malignant Biliary Lesions. United States and Canadian Academy of Pathology, 2012 (poster)

Phillips GDK, Jain D, Torbenson M, Wu T-T, Yeh MMC, and Kakar S. Comparison of Hepatocellular Markers for Diagnosis of Poorly−Differentiated Hepatocellular Carcinoma: High Sensitivity with Combined Use of Arginase −1 and Glypican−3. United States and Canadian Academy of Pathology, 2012 (poster)

Cho S, Wanless I, Paradis V, Pai R, Biolac-Sage P, Alves V, Souza T, Makhlouf H, Schirmacher P, Evason K, and Ferrell L. FNH-Like Lesions and Glutamine Synthetase Expression in the Liver in Hereditary Hemorrhagic Telangiectasia. United States and Canadian Academy of Pathology, 2011 (platform)

Doherty A, Ferrell L, Morse C, and Kleiner D. Hepatic Pigment Accumulation in HIV Patients on HAART Therapy. United States and Canadian Academy of Pathology, 2011 (poster)

Krings G, Jain D, Wu T, Yeh M, Torbenson M, and Kakar S. Immunohistochemical pitfalls and the importance of glypican-3 in the diagnosis of cirrhosis hepatocellular carcinoma. United States and Canadian Academy of Pathology, 2011 (poster)

Brandman D, Pingitore A, Feng S, Ferrell L, Bass NM, and Terrault NA. Evolution from steatosis to steatohepatitis post-liver transplantation: relationship to fibrosis progression and the metabolic 
syndrome in hepatitis C virus (HCV)-infected recipients. American Association for the Study of Liver Diseases, 2010 (platform)

Brandman D, Pingitore A, Lai J, Roberts J, Ferrell L, Bass N, and Terrault N. Hepatic steatosis predicts risk of advanced fibrosis in liver transplantation recipients with recurrent hepatitis C virus. American Transplant Congress, 2010 (poster)

Cho S, Paradis V, Pai R, Bioulac-Sage P, Alves V, Souza T, Makhlouf H, Schirmacher P, Evason K, and Ferrell L. Histopathologic Features of Extensive Hepatic Vascular Malformations. Mod Pathol 24 (Supple 1): Jan 10, 2010. United States and Canadian Academy of Pathology, Washington, DC, 2010 (poster)

Evason K, Grenert J, Ferrell L, and Kakar S. Immunohistochemical Classification of Hepatic Adenomas and Atypical Hepatocellular Neoplasms: Correlation with Clinicopathologic Characteristics and Chromosomal Abnormalities. Mod Pathol 24 (Supple 1): Jan 10, 2010. United States and Canadian Academy of Pathology, 2010 (poster)

Gill RM, Bass NM, and Ferrell LD. Characterization of CD34 Expression in Nonalcoholic Steatohepatitis, Mod Pathol 24 (Supple 1): Jan 10, 2010. United States and Canadian Academy of Pathology, 2010 (platform)

Mattis AN, Browne LW, Kakar S, Chen YY, Kim GE, and Ferrell L. Comparison of PAX−2 and PAX−8 in Distinguishing Hepatocellular Carcinomas with Clear−Cell Morphology from Renal Cell Carcinomas. Mod Pathol 24 (Supple 1): Jan 10, 2010. United States and Canadian Academy of Pathology, Washington, DC, 2010 (poster)

Mattis AN, Fischer S, Makhlouf H, Tsui W, Cho S, and Ferrell L. Problematic Cavernous Hemangioma Variants and Other Benign Mimics. Mod Pathol 24 (Supple 1): Jan 10, 2010. United States and Canadian Academy of Pathology, Washington, DC, 2010 (poster)

Evason K, Bove KE, Knisely AS, Rhee S, Rosenthal P, Miethke A, Ferrell1 LD, and Kim GE. Morphological Findings In Progressive Familial Cholestasis 2 (PFIC2): Correlation With Genetic And Immunohistochemical Studies. Amer J Surg Pathol, 2011;35(5):687-96. Society for Pediatric Pathology, 2009 (platform presentation). United States and Canadian Academy of Pathology, 2009 (platform presentation)

Lam M, Torbenson M, Yeh M, Vivekanandan P, and Ferrell L. HFE Gene Mutation in AAT Deficiency and HCV Cirrhosis. Mod Pathol 22 (Supple 1): Jan 09, 313A. United States and Canadian Academy of Pathology, 2009 (poster)

Ramachandran R, Browne LW, and Kakar S. Advantages and pitfalls of glypican-3 immunohistochemistry in the distinction of hepatocellular carcinoma and metastatic carcinomas. United States and Canadian Academy of Pathology, 2009 (poster)

Browne LW, Tan VO, Kakar S, Chen YY, Kim GK and Ferrell LD. Immunohistochemistry for PAX-2 Distinguishes Hepatocellular Carcinomas with Clear-Cell Morphology from Renal Cell Carcinomas. Mod Path 21 (supple 1): Jan 08. United States and Canadian Academy of Pathology, 2008 (poster)

Doherty AR, Stock PG, Roland ME, Barin B, Terrault NA, and Ferrell LD. A novel Hepatitic/Ductular Lesion in HIV-Hepatitis C (HCV) Coinfected Liver Transplant Patients. Mod Path 21 (supple 1): Jan 08. United States and Canadian Academy of Pathology, 2008 (platform)

Fenton H, Torbenson M, Vivekanandan P and Ferrell L. Marked Iron Accumulation in Liver Explants: A Risk Factor for Cardiac Failure (CF) Even in the absence of Major Gene Defects of Hereditary. Mod Path 21 (supple 1): Jan 08. United States and Canadian Academy of Pathology, 2008 (poster)

Pingitore A, Kim G, Rosenthal G and Ferrell L. Atypical Neonatal Obstructive Liver Disease 
(NOLD): Variants of Biliary Atresia (BA) or Not? Mod Path 21 (supple 1): Jan 08. United States and Canadian Academy of Pathology, 2008 (Stowell-Orbison/Autopsy Award Poster)

Tan V, Browne LW, and Ferrell LD. Specific definitions of fatty change in transplant donor liver biopsies increase interobserver agreement. Mod Path 20 (Suppl 2): Jan 07. United States and Canadian Academy of Pathology, San Diego, CA, 2007 (poster)

Yabes A, Naini B, Lassman C, Yeh MM, Jakate S, Torbenson M, Nakhleh RE, Portmann B, Tomezzoli A, and Ferrell LD. Cirrhosis-like Hepatocellular Carcinoma (HCC): A rare and often clinically-undetected variant. Mod Path 20 (Suppl 2): Jan 07. United States and Canadian Academy of Pathology, 2007 (platform)

Yabes A, Burgart L, Jain D, and Kakar S. Chromosomal Changes in Fibrolamellar Hepatocellular Carcinoma Determined by Array-Based Comparative Genomic Hybridization. United States and Canadian Academy of Pathology, San Francisco, 2007 (poster)

Yabes A, Davern T, and Ferrell L. The histologic features of prolonged hepatic acetaminophen toxicity. International Academy of Pathology, 2006 (poster)
 

Yabes A and Ferrell L. Centrizonal ductular reaction in subacute and chronic liver disease. Mod Path, 19 (Suppl 1): 238A, Jan 2006. United States and Canadian Academy of Pathology, 2006 (poster)