Shibani Pati, MD, PhD

Shibani Pati, MD, PhD

Professor in Residence Department of Laboratory Medicine; Professor Department of Surgery (Joint Appt); Director Center for Translational Research in Transfusion Medicine and Cellular Therapies
Laboratory Medicine
Specialty Areas
Transfusion Medicine and Cell Therapies

UCSF
Laboratory Medicine, Box 0100
513 Parnassus Avenue, HSE-715
San Francisco, CA 94143
United States

Research and Clinical Interests

I am currently the Director of the Center for Research Transfusion Medicine and Cell Therapies (CTMCT). My main goal is to foster multidisciplinary collaborations that advance the fields of transfusion medicine (TM) and cellular therapeutics (CT). My lab's research is focused on the role of endothelial dysfunction and vascular compromise in the pathogenesis of human disease. My specific areas of investigation involve the use of stem cells and novel resuscitative modalities, including blood products, that can mitigate endothelial dysfunction or the endotheliopathy of trauma (EOT) in traumatic injury.

I am also the main organizer of  CTTACC- Cellular Therapies and Transfusion Medicine in Trauma and Critical Care Medicine Conference. We have now organized and hosted five conferences that have been focused upon cellular therapies in trauma and critical care. The website for the meeting is www.cttacc.org. The next CTTACC conference is scheduled for May 4-7, 2025 in Scottsdale, AZ. The conference is co-hosted by Colorado State University and The Armed Forces Institute of Regenerative Medicine (AFIRM).The goal of this meeting is to bring together the expertise and input of blood bankers, clinicians running trials, basic scientists, companies, FDA, NIH, AABB, BARDA, ISCT, ARPA-H, and the DOD  to discuss existing barriers in the translation of cell therapies in trauma and critical care medicine, a field with few therapeutic options. This year's conference will have a Military Health session focused on the prolonged field care of combat casualties.

Selected Publications
  • Pati S, Rasmussen TE. Cellular therapies in trauma and critical care medicine: Looking towards the future. PLoS Med. 2017 Jul 11;14(7):e1002343. doi: 10.1371/journal.pmed.1002343. eCollection 2017 Jul. PMID: 28700606
  • Pati S, Pilia M, Grimsley JM, Karanikas AT, Oyeniyi B, Holcomb JB, Cap AP, Rasmussen TE. Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers SHOCK 2015 Dec;44(6):505-23.
  • Gyulnar Baimukanova, Byron Miyazawa, Daniel Potter, Marcus Muench, Roberta Bruhn, Stuart L. Gibb, Philip C. Spinella, Andrew P. Cap, Mitchell Cohen, Shibani Pati. Platelets Regulate Vascular Endothelial Stability: Assessing the Storage Lesion and Donor Variability of Apheresis Platelets. Transfusion. 2016 Mar;56 Suppl1:S65-75. doi: 10.1111/trf.13532.
  • Gyulinar Baikumanova, Byron Miyazawa, Daniel Potter, Stuart Gibb, Sheila Keating, Ali Danesh, Ashley Beyer, Yelena Dayter, Roberta Bruhn, Marcus Muench, Andrew P. Cap, Philip J. Norris, Philip Spinella, Mitchell Cohen and Shibani Pati. The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function Transfusion. 2016 Mar;56 Suppl 1:S52-64. doi: 10.1111/trf.13455.
  • Pati S, Potter DR, Baikamunova G, Farrell DH, Holcomb JB, Schreiber MA. Modulating the Endotheliopathy of Trauma: factor Concentrate vs. Fresh Frozen Plasma J Trauma Acute Care Surg. 2016 Jan 21.
Awards
  • 2009 Mission Connect Award (TIRR Foundation) for research in High throughput Screening of Drugs
  • 2009 Mission Connect (TIRR Foundation Award) for the study of the Immunomodulatory effects of MAPCs in TBI
  • 2006 Vivian L. Smith Postdoctoral Fellow Award in Neurocognitive Disorders
  • 2007 NIH LRP Award for Pediatric Research in TBI
  • 2009 NIH LRP Award for Pediatric Research in TBI
  • 2009 Mission Connect Award (TIRR Foundation) for research in High throughput Screening of Drugs for motor neuron stem cell differentiation and survival
  • 2011 Scott Murphy Guest Lectureship BEST/AABB San Diego
  • 2014 Blood Systems Inc. TOP Performer $10,000 Award
  • 2015 Shelton Foundation Neuro-military Award for Research in TBI
  • 2017 UCSF Chancellor's Mid-Career Recruitment Award
  • 2018 Scientific Membership Award BEST Organization
  • 2023 10 Years of Service as Chair to CTTACC conference
  • 2024 Distinguished Founder's Lecture and Prize Western Trauma Association
  • 2024 Ernest Moore and Sarah Druzer Distinguished Lecture Surgery Grand Rounds University of Colorado
Additional Information

Specialty Areas

  • Stem cell therapeutics and stem cell derived factors in trauma and critical care medicine
  • Control of vascular leak in disease and mitigating endothelial damage
  • Novel Resuscitative Modalities- plasma (FFP), platelets, Lyophilized plasma, pathogen reduced plasma, dried platelets, factor concentrate
  • Storage Lesion of FFP and Platelets
  • Trauma induced ARDS, Stem cell therapies in traumatic brain injury (TBI) and spinal cord injury (SCI)