Sheila M. Keating, PhD, MSPH
Vitalant Research Institute
270 Masonic Avenue
San Francisco, CA 94118
United States
My main career focus is to understand immune mechanisms of a disease, and to understand and direct the protective responses to prevent infection and reduce inflammation-associated pathology. In order to do this I have focused on identifying biomarkers and discovering immune therapeutics that may be associated with disease-induced inflammation and pathogenesis. I have focused on biomarker discovery using high throughput immune assays to measure cytokines, chemokines, growth factors and other biomarkers of immune response or pathology ranging from HIV, HCV, HBV vaccine breakthrough, Chagas, West Nile Virus, cardiovascular disease, neuropathology and many other areas.
- Keating SM, Pilcher CD, Jain V, Lebedeva M, Hampton D, Abdel-Mohsen M, Deng X, Murphy G, Welte A, Facente SN, Hecht F, Deeks SG, Pillai SK, Busch MP. HIV Antibodies Detect HIV Persistence and Low Level Viral Replication. J Infect Dis. 2017.
- Jacobs ES, Keating SM (co-first author), Abdel-Mohsen M, Gibb SL, Heitman JW, Inglis HC, Martin JN, Zhang J, Kaidarova Z, Deng X, Wu S, Anastos K, Crystal H, Villacres MC, Young M, Greenblatt RM, Landay AL, Gange SJ, Deeks SG, Golub ET, Pillai SK, Norris PJ. Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication in vitro and Modulate HIV Restriction Factor Expression. J Virol. 2017.
- Keating SM, Heitman JW, Wu S, Deng X, Stacey AR, Zahn RC,de la Rosa M, Finstad SL, Lifson JD, Piatak M, Gauduin MC, Kessler BM, Ternette N, Carville A, Johnson RP, Desrosiers RC, Letvin NL, Borrow P, Norris PJ, Schmitz JE. 2015. Magnitude and quality of cytokine and chemokine storm during acute infection distinguish non-pathogenic and pathogenic simian immunodeficiency virus infections of nonhuman primates. J Virol. 2016
- Keating SM, Pilcher CD, Busch MP. Timing is Everything - Shortcomings of Current HIV Diagnostics in the Early Treatment Era. Clin Infect Dis. 2016 Jun 17.
- Keating SM, Deng X, Fernandes F, Cunha-Neto E, Ribeiro AL, Adesina B, Beyer AI, Contestable P, Custer B, Busch MP, Sabino EC; NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component.Inflammatory and cardiac biomarkers are differentially expressed in clinical stages of Chagas disease. Int J Cardiol. 2015 Nov
- 2005 Dorothy Price Medal for Immunology, National University Ireland, Kildare, Ireland
- 2010 CFAR Women and HIV Junior Scholar Award
- 2011 CHAVI Young Investigator