Marta Margeta, MD, PhD

Marta Margeta, MD, PhD

Associate Professor, Medical Director of Neuromuscular Pathology Laboratory, Associate Director of Undergraduate Pathology Education
Pathology
Division
Neuropathology
Specialty Areas
Neuropathology
Neuromuscular Pathology
Pathology Education
Neuroscience Research

UCSF
Pathology, Box 0511
513 Parnassus Avenue, Room HSW-514
San Francisco, CA 94143
United States

Hospital Affiliations
UCSF Parnassus Heights
Other UCSF Organizational Association(s)

Biomedical Sciences (BMS) Graduate Program

Research and Clinical Interests

Biological stress response pathways play a critical role in the prevention and/or repair of cell and tissue injury; however, unchecked activation of these pathways can be harmful, resulting in disease and even premature death. The long term goal of my basic and translational research is to elucidate how activation of stress response signaling in skeletal muscle and the brain affects neurologic disease; to this end, my lab uses human tissue and animal / cellular models of disease to investigate the role of three distinct but related stress response pathways - (1) the Keap1/Nrf2 antioxidant pathway, (2) autophagy, and (3) astrocyte activation in response to injury. In addition, I am interested in curriculum design and curricular innovation, and perform educational research in these areas

Selected Publications
  • Margeta M.: Autophagy defects in skeletal myopathies. Annu Rev Pathol (2019, in press)
  • Duleh S., Wang X., Komirenko A., and Margeta M.; Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies. Acta Neuropathol Commun 4:115 (2016)
  • Habas A., Hahn J., Wang X., and Margeta M. Neuronal activity regulates astrocytic Nrf2 signaling. Proc Natl Acad Sci USA 45:18291-6 (2013)
  • Hiniker A., Daniels B.H., Lee H.S., Margeta M. Comparative utility of LC3, p62 and TDP-43 immunohistochemistry in differentiation of inclusion body myositis from polymyositis and related inflammatory myopathies. Acta Neuropathol Commun 1:29 (2013)
  • Lee H.S., Daniels B.H., Salas E., Bollen A.W., Debnath J., and Margeta M. Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: A case-control study. PloS ONE 7:e36221 (2012)

Complete Publications on PubMed

Awards
  • 2018 Election to the Haile T. Debas UCSF Academy of Medical Educators
  • 1996 Klaus R. Unna Award, for outstanding research accomplishments as a graduate student
  • 1990 University of Zagreb Chancellor’s Award, for outstanding academic performance as a medical student
Additional Information