Lucy Kornblith, MD

Lucy Kornblith, MD

Associate Professor
Laboratory Medicine
Division
Surgery

UCSF
Laboratory Medicine, Box 0807
2540 23rd Street, Room 2903
San Francisco, CA 94110
United States

Research and Clinical Interests

Lucy Zumwinkle Kornblith, M.D., F.A.C.S. received her undergraduate degree from University of California Santa Barbara, her M.D. from the University of Colorado, completed her General Surgery residency at the University of California San Francisco (UCSF), a Trauma and Critical Care Clinical Translational Research Fellowship at UCSF, and subspecialty training in Trauma and Acute Care Surgery and Surgical Critical Care at UCSF prior to joining the faculty at UCSF.

She clinically practices Trauma Surgery, Acute Care Surgery, and Surgical Critical Care. She has played a pivotal role in the translational study of blood system failure after injury, centrally focused on post-injury platelet biology. Her research program is multi-pronged, covering 1) Translational research to identify novel biology of blood system failure through the lens of platelets, 2) Large observational studies to identify predictors of bad outcomes after injury, and 3) Clinical trials investigating therapeutics and resuscitation strategies for injured patients. Her research program has been funded by the National Institutes of Health, the Department of Defense, the American College of Surgeons, the Eastern Association for the Surgery of Trauma, the UCSF School of Medicine Irene Perstein Award, and the Doris Duke Charitable Foundation. Dr. Kornblith is the Department of Surgery Director of Gender Equity and a co-chair of the UCSF Department of Surgery Muriel Steele Society, an inclusive community dedicated to inspiring, supporting, and promoting 400+ women surgeons so they can thrive at all stages of their careers.

Selected Publications
  • Kornblith LZ, Decker A, Conroy AS, Hendrickson CM, Fields AT, Robles AJ, Callcut RA, Cohen MJ; It's About Time: Transfusion Effects on Post-Injury Platelet Aggregation Over Time.; The Journal Of Trauma And Acute Care Surgery; 2019
  • Kornblith LZ, Moore HB, Cohen MJ; Trauma-induced coagulopathy: The past, present, and future.; Journal Of Thrombosis And Haemostasis : JTH; 2019
  • Kornblith LZ, Robles AJ, Conroy AS, Hendrickson CM, Calfee CS, Fields AT, Callcut RA, Cohen MJ; Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury.; The Journal Of Trauma And Acute Care Surgery; 2018
  • Solomon SD, Lowenstein CJ, Bhatt AS, Peikert A, Vardeny O, Kosiborod MN, Berger JS, Reynolds HR, Mavromichalis S, Barytol A, Althouse AD, Luther JF, Leifer ES, Kindzelski AL, Cushman M, Gong MN, Kornblith LZ, Khatri P, Kim KS, Baumann Kreuziger L, Wahid L, Kirwan BA, Geraci MW, Neal MD, Hochman JS, ACTIV4a Investigators; Effect of the P-selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial.; Circulation; 2023
  • Berger JS, Neal MD, Kornblith LZ, Gong MN, Reynolds HR, Cushman M, Althouse AD, Lawler PR, McVerry BJ, Kim KS, Baumann Kreuziger L, Solomon SD, Kosiborod MN, Berry SM, Bochicchio GV, Contoli M, Farkouh ME, Froess JD, Gandotra S, Greenstein Y, Hade EM, Hanna N, Hudock K, Hyzy RC, Ibáñez Estéllez F, Iovine N, Khanna AK, Khatri P, Kirwan BA, Kutcher ME, Leifer E, Lim G, Lopes RD, Lopez-Sendon JL, Luther JF, Nigro Maia L, Quigley JG, Wahid L, Wilson JG, Zarychanski R, Kindzelski A, Geraci MW, Hochman JS, ACTIV-4a Investigators; Effect of P2Y12 Inhibitors on Organ Support-Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial.; JAMA Network Open; 2023
  • Matthay ZA, Fields AT, Wick KD, Jones C, Lane HC, Herrera K, Nuñez-Garcia B, Gennatas E, Hendrickson CM, Kornblith AE, Matthay MA, Kornblith LZ, COVID-19 Associated Coagulopathy Inflammation Thrombosis (Co-ACIT) Study Group; Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19.; Frontiers In Immunology; 2023
  • Fields AT, Andraska EA, Kaltenmeier C, Matthay ZA, Herrera K, Nuñez-Garcia B, Jones CM, Wick KD, Liu S, Luo JH, Yu YP, Matthay MA, Hendrickson CM, Bainton RJ, Barrett TJ, Berger JS, Neal MD, Kornblith LZ; Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior.; Frontiers In Immunology; 2023
  • Matthay ZA, Fields AT, Nunez-Garcia B, Park JJ, Jones C, Leligdowicz A, Hendrickson CM, Callcut RA, Matthay MA, Kornblith LZ; Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury.; Journal Of Thrombosis And Haemostasis : JTH; 2022
  • Matthay ZA, Hellmann ZJ, Nunez-Garcia B, Fields AT, Cuschieri J, Neal MD, Berger JS, Luttrell-Williams E, Knudson MM, Cohen MJ, Callcut RA, Kornblith LZ; Postinjury platelet aggregation and venous thromboembolism.; The Journal Of Trauma And Acute Care Surgery; 2022
  • Knudson MM, Moore HB, Moore EE, Kornblith LZ, Kiraly LN, McNutt MK, Wade CE, Bruns BR, Sauaia A; Tissue plasminogen activator resistance is an early predictor of posttraumatic venous thromboembolism: A prospective study from the CLOTT research group.; The Journal Of Trauma And Acute Care Surgery; 2022
  • Knudson MM, Moore EE, Kornblith LZ, Shui AM, Brakenridge S, Bruns BR, Cipolle MD, Costantini TW, Crookes BA, Haut ER, Kerwin AJ, Kiraly LN, Knowlton LM, Martin MJ, McNutt MK, Milia DJ, Mohr A, Nirula R, Rogers FB, Scalea TM, Sixta SL, Spain DA, Wade CE, Velmahos GC; Challenging Traditional Paradigms in Posttraumatic Pulmonary Thromboembolism.; JAMA Surgery; 2022
  • Fields AT, Lee MC, Mayer F, Santos YA, Bainton CMV, Matthay ZA, Callcut RA, Mayer N, Cuschieri J, Kober KM, Bainton RJ, Kornblith LZ; A new trauma frontier: Exploratory pilot study of platelet transcriptomics in trauma patients.; The Journal Of Trauma And Acute Care Surgery; 2022
  • Berger JS, Kornblith LZ, Gong MN, Reynolds HR, Cushman M, Cheng Y, McVerry BJ, Kim KS, Lopes RD, Atassi B, Berry S, Bochicchio G, de Oliveira Antunes M, Farkouh ME, Greenstein Y, Hade EM, Hudock K, Hyzy R, Khatri P, Kindzelski A, Kirwan BA, Baumann Kreuziger L, Lawler PR, Leifer E, Lopez-Sendon Moreno J, Lopez-Sendon J, Luther JF, Nigro Maia L, Quigley J, Sherwin R, Wahid L, Wilson J, Hochman JS, Neal MD, ACTIV-4a Investigators; Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial.; JAMA; 2022
  • Barrett TJ, Cornwell M, Myndzar K, Rolling CC, Xia Y, Drenkova K, Biebuyck A, Fields AT, Tawil M, Luttrell-Williams E, Yuriditsky E, Smith G, Cotzia P, Neal MD, Kornblith LZ, Pittaluga S, Rapkiewicz AV, Burgess HM, Mohr I, Stapleford KA, Voora D, Ruggles K, Hochman J, Berger JS; Platelets amplify endotheliopathy in COVID-19.; Science Advances; 2021
  • REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R; Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.; The New England Journal Of Medicine; 2021
  • ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Džavík V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, García-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pérez González YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R; Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.; The New England Journal Of Medicine; 2021
  • Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schöchl H, Hunt BJ, Sauaia A; Trauma-induced coagulopathy.; Nature Reviews. Disease Primers; 2021
  • Fields AT, Matthay ZA, Nunez-Garcia B, Matthay EC, Bainton RJ, Callcut RA, Kornblith LZ; Good Platelets Gone Bad: The Effects of Trauma Patient Plasma on Healthy Platelet Aggregation.; Shock (Augusta, Ga.); 2021
  • Matthay ZA, Fields AT, Nunez-Garcia B, Patel MH, Cohen MJ, Callcut RA, Kornblith LZ; Dynamic effects of calcium on in vivo and ex vivo platelet behavior after trauma.; The Journal Of Trauma And Acute Care Surgery; 2020
  • Vulliamy P, Kornblith LZ, Kutcher ME, Cohen MJ, Brohi K, Neal MD; Alterations in platelet behavior after major trauma: adaptive or maladaptive?; Platelets; 2020
  • Lucy Z. Kornblith, Anamaria J. Robles, Amanda S. Conroy, Byron Y. Miyazawa, Rachael A. Callcut, Mitchell J. Cohen; Tired Platelet: Functional Anergy after Injury.; Journal Of The American College Of Surgeons; 2017