Kanish Mirchia, MD
Clinical Instructor
Pathology
Division
Neuropathology
Specialty Areas
Neuropathology
Molecular Diagnostics
UCSF
Pathology, Box 0102
505 Parnassus Avenue
San Francisco, CA 94143
United States
Hospital Affiliations
UCSF Parnassus Heights
UCSF Mission Bay
Research and Clinical Interests
My scientific goals entail three major domains comprising accurate molecular classification of brain tumors, genomic analysis to elucidate the mechanisms underlying tumor heterogeneity, and the development of deep learning single cell and spatial transcriptomic technologies to enable biologic discovery.
Selected Publications
- Mirchia K, Sathe AA, Fudym Y, Galbraith K, Viapiano M, Walker JM, Snuderl M, Xing C, Hatanpaa KJ, Richardson TE. Total Copy Number Variation as a Prognostic Factor in Adult Astrocytoma Subtypes. Acta Neuropathologica Communications. 2019 Jun 10. PMID: 31177992; https://doi.org/10.1186/s40478-019-0746-y
- Mirchia K, Snuderl M, Galbraith K, Hatanpaa KJ, Walker JM, Richardson TE. Establishing a Prognostic Threshold for Total Copy Number Variation within Adult IDH-mutant grade II/III Astrocytomas. Acta Neuropathologica Communications. 2019 Jul 22. PMID: 31349875
- Calixto-Hope Lucas, Kanish Mirchia, Kyounghee Seo et al. Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution, 16 May 2023, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-2921804/v1]
- Raleigh D, Mirchia K, Choudhury A, Joseph T, Birrueta J, Phillips J, Bhaduri A, Crouch E, Perry A. Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis. Res Sq [Preprint]. 2023 Jul 26:rs.3.rs-3164953. doi: 10.21203/rs.3.rs-3164953/v1. PMID: 37546798; PMCID: PMC10402198.
- Chen W, Choudhury A, Youngblood M, Polley MY, Lucas CH, Mirchia K, Maas S, Suwala A, Won M, Bayley J, Harmanci A, Harmanci A, Klisch T, Nguyen M, Vasudevan H, McCortney K, Yu T, Bhave V, Lam TC, Pu J, Leung G, Chang J, Perlow H, Palmer J, Haberler C, Berghoff A, Preusser M, Nicolaides T, Mawrin C, Agnihotri S, Resnick A, Rood B, Chew J, Young J, Boreta L, Braunstein S, Schulte J, Butowski N, Santagata S, Spetzler D, Bush NAO, Villanueva-Meyer J, Chandler J, Solomon D, Rogers C, Pugh S, Mehta M, Sneed P, Berger M, Horbinski C, McDermott M, Perry A, Bi W, Patel A, Sahm F, Magill S, Raleigh DR. Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Nature Medicine. Published: 2023 Nov 09. Nature Medicine. PMID: 36993741.
- Zhu I, Miller K, Mirchia K, Payne E, Pak J, Jacques L, Braunstein SE, Vasudevan HN. Malignant Peripheral Nerve Sheath Tumors Activate Distinct Immunosuppressive Pathways Following Radiotherapy and are Associated with Immune Depletion In Vivo. ASTRO 2023; International Journal of Radiation Oncology, Biology, Physics, 117(2), S168. doi: 10.1016/j.ijrobp.2023.06.269
- Vasudevan, H.N., Payne, E., Delley, C.L., Liu S, Mirchiak K, et al. Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance. Nat Commun 15, 477 (2024). https://doi.org/10.1038/s41467-024-44755-9
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