Iwei Yeh, MD, PhD

Iwei Yeh, MD, PhD

Associate Director, Clinical Cancer Genomics Laboratory
Specialty Areas

Pathology, Box 1790
1701 Divisadero Street, Suite 280
San Francisco, CA 94143
United States

Research and Clinical Interests

The unifying theme of my work is to understand the genetic mechanisms involved in the development and progression of melanocytic skin tumors and harness our understanding to improve melanoma diagnosis treatment.

Selected Publications
  • Yeh I, Jorgenson E, Shen L, Xu M, North JP, Shain AH, Reuss D, Wu H, RobinsonWA, Olshen A, von Deimling A, Kwok PY, Bastian BC, Asgari MM. Targeted genomic profiling of acral melanoma. J Natl Cancer Inst. 2019 Jan 18. doi: 10.1093/jnci/djz005. [Epub ahead of print] PubMed PMID: 30657954.
  • Ablain J, Xu M, Rothschild H, Jordan RC, Mito JK, Daniels BH, Bell CF, Joseph NM, Wu H, Bastian BC, Zon LI, Yeh I. Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Science. 2018 Nov30;362(6418):1055-1060. doi: 10.1126/science.aau6509. Epub 2018 Nov 1. PubMed. PMID: 30385465.
  • Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph NM, Yeh I, Bastian BC, Judson RL. Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation. Cancer Cell. 2018 Jul 9;34(1):56-68.e9. doi: 10.1016/j.ccell.2018.05.014. PubMed PMID: 29990501; PubMed Central PMCID: PMC6084788.
  • Shain AH, Joseph NM, Yu R, Benhamida J, Liu S, Prow T, Ruben B, North J, Pincus L, Yeh I, Judson R, Bastian BC. Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution. Cancer Cell. 2018 Jul 9;34(1):45-55.e4. doi: 10.1016/j.ccell.2018.06.005. PubMed PMID: 29990500; PubMed Central PMCID: PMC6319271.
  • Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardière A. Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi. Nat Commun. 2017 Sep 21;8(1):644. doi: 10.1038/s41467-017-00758-3. PubMed PMID: 28935960; PubMed Central PMCID: PMC5608693.