Huimin Geng, PhD

Huimin Geng, PhD

Associate Adjunct Professor
Laboratory Medicine
Specialty Areas
Genomics/Epigenomics in Lymphoma/Leukemia

Laboratory Medicine, Box 0451
513 Parnassus Avenue, Room S-1457A
San Francisco, CA 94143
United States

Research and Clinical Interests

My research is focused on functional genomics and epigenomics of lymphoma and leukemia using computational approaches on genome-wide array and deep sequencing data, including RNA-seq, Whole Exome-Seq, ChIP-seq, miRNA-seq and DNA methylation eRRBS-seq. Applying bioinformatic methods coupled with in vitro and in vivoexperiments, we are interested in identifying and evaluating new prognostic and disease-classification biomarkers and novel therapeutic targets for different forms of lymphoma and leukemia.

Selected Publications
  • Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA & Müschen M. Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia. Nature (2015). In press.
  • Geng H*, Hurtz C*, Lenz KB*, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Gang X, Lee JW, Deucher A, Qi J, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Burger JA, Milne T, Chang BH, & Müschen M. Self-enforcing feedback activation between BCL6 and tonic pre-B cell receptor signaling defines a distinct subtype of human acute lymphoblastic leukemia. Cancer Cell 27(3): 409–425 (2015). *Co-first authors
  • Kharabi-Masouleh B, Geng H, Hurtz C, Huang C, Chan LN, Ramezani-Rad P, Silveira VS, Cazzaniga V, Swaminathan S, Sun H, Koeffler HP, Melnick A, Glimcher LH & Müschen M. The plasma cell transcription factor XBP1 is required to mitigate the unfolded protein response in Ph+ ALL. Proc Natl Acad Sci. 111(21): E2219–28 (2014)
  • Huang C, Geng H, Boss I, Wang L & Melnick A. Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation. Blood 123(7):1012-20. (2014)
  • Chambwe N, Kormaksson M, Geng H, De S, Michor F, Johnson NA, Morin RD, Scott DM, Godley LA, Gascoyne RD, Melnick AM, Campagne F & Shaknovich R. Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes. Blood 123(11):1699-708 (2014)

For a full publication list in PubMed: