Gary A. Jarvis, PhD
Gram-negative Bacterial Infections
SFVAHCS, Dept. 111W1
4150 Clement Street
San Francisco, CA 94121
Research and Clinical Interests
My research interests include: 1) Regulation of complement activation by blood-borne Gram-negative bacteria; 2) Development of vaccines for meningococcal meningitis and gonorrhea; 3) Complement deficiencies and susceptibility to bacterial sepsis; 4) Role of innate immune receptors in Gram-negative bacterial infections.
- Liu, M., C. M. John, and G. A. Jarvis. 2014. Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a. J. Immunol. 192:1768-1777.
- John C. M., N. J. Phillips, R. Din, M. Liu, E. Rosenqvist, E. A. Høiby, D. C. Stein, and G. A. Jarvis. 2016. Lipooligosaccharide structures of invasive and carrier isolates of Neisseria meningitidis are correlated with pathogenicity and carriage. J. Biol. Chem. 291:3224-3238.
- Anandan, A., G. L. Evans, K. Condic-Jurkic, M. L. O’Mara, C. M. John, N. J. Phillips, G. A. Jarvis, S. S. Wills, K. A. Stubbs, I. Isabel Moraes, C. M. Kahler, and A. Vrielink. 2017. Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding. Proc. Natl. Acad. Sci. USA. 114:2218-2223.
- John, C. M., D. Feng, and G. A. Jarvis. 2018. Treatment of human challenge and antibiotic-resistant strains of Neisseria gonorrhoeae with LpxC inhibitors. J. Antimicrob. Chemother. 73:2064-2071.
- Brunner, K., C. M. John, N. J. Phillips, D. G. Alber, M. R. Gemmell, R. Hansen, H. L. Nielsen, G. L. Hold, M. Bajaj-Elliot, and G. A. Jarvis. 2018. Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence. J. Lipid Res. 59:1893–1905.