Edward Thornborrow, MD, PhD
Professor, UCSF Department of Laboratory Medicine
Laboratory Medicine
Division
Hematopathology
Specialty Areas
Hematopathology
UCSF
Pathology, Box 0100
185 Berry Street, Room CB2131
San Francisco, CA 94158
United States
Hospital Affiliations
UCSF Mission Bay
UCSF Parnassus Heights
UCSF Mount Zion
Research and Clinical Interests
My interests include the diagnosis and study of hematologic malignancies with an emphasis on identifying novel sets of markers that provide clinically relevant diagnostic and prognostic information. In addition, I am interested in the development and implementation of new laboratory testing methodologies and quality improvement procedures that allow us to better serve our patient population.
Selected Publications
- Thornborrow, EC, Maurer, M, and Manfredi, JJ. Electrophoretic Mobility Shift Analysis of the DNA binding of Tumor Suppressor Gene Products, in Tumor Suppressor Genes, Methods and Protocols, Methods in Molecular Medicine Series, Wafik S. El-Deiry (ed.), Humana Press, USA, 223:87-100, 2003.
- Thornborrow, EC, Patel, S, Mastropietro, AE, Schwartzfarb, EM, and Manfredi, JJ. A Conserved Intronic Response Element Mediates DirectP53-dependent Transcriptional Activation of Both the Human and Murine BAX Genes, Oncogene. 21:990-999, 2002.
- Thornborrow, EC, and Manfredi, JJ. The Tumor Suppressor Protein P53 Requires a Cofactor to Activate Transcriptionally the Human BAX Promoter, Journal of Biological Chemistry. 276: 15598-15608, 2000.
- Thornborrow, EC, and Manfredi, JJ. One Mechanism for Cell Type-specific Regulation of the BAX promoter by the Tumor Suppressor p53 is Dictated by the p53 Response Element, Journal of Biological Chemistry. 274: 33747-33756, 1999.