Daniel A. Mordes, MD, PhD

Daniel A. Mordes, MD, PhD

Assistant Professor
Pathology
Division
Neuropathology
Specialty Areas
Neuropathology

UCSF
Pathology, Box 0518
675 Nelson Rising Lane
San Francisco, CA 94158
United States

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UCSF Profiles

Hospital Affiliations
UCSF Mission Bay
Research and Clinical Interests

Principal Investigator and Assistant Professor in the Department of Pathology and Institute for Neurodegenerative Diseases (IND) at UCSF. My research group uses stem cell-based neuronal models and patient brain samples to study neurodegeneration, including ALS, and is based in the new Weill Neurosciences Building at Mission Bay.

My clinical interests focus on diagnostic neuropathology, particularly dementia and other neurodegenerative diseases.

Selected Publications
  • Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice. Neuron. 2020 11 25; 108(4):775-783.e4. Mordes DA, Morrison BM, Ament XH, Cantrell C, Mok J, Eggan P, Xue C, Wang JY, Eggan K, Rothstein JD. PMID: 33022228.
  • Kinetics of a-synuclein prions preceding neuropathological inclusions in multiple system atrophy. PLoS Pathog. 2020 02; 16(2):e1008222. Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB. PMID: 32017806.
  • Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nat Neurosci. 2019 12; 22(12):1966-1974. Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Al Khleifat A, Mordes DA, Ghosh S, ALSGENS Consortium , FALS Consortium , Project MinE Consortium , CReATe Consortium , Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM. PMID: 31768050.
  • Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines. Acta Neuropathol. 2019 03; 137(3):437-454. Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB. PMID: 30690664.
  • ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nat Neurosci. 2019 02; 22(2):167-179. Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K. PMID: 30643292.
  • Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathol Commun. 2018 07 04; 6(1):55. Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K. PMID: 29973287.
  • The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Genes Dev. 2018 07 01; 32(13-14):929-943. Zhang Y, Burberry A, Wang JY, Sandoe J, Ghosh S, Udeshi ND, Svinkina T, Mordes DA, Mok J, Charlton M, Li QZ, Carr SA, Eggan K. PMID: 29950492.
  • Familial Parkinson's point mutation abolishes multiple system atrophy prion replication. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):409-414. Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB. PMID: 29279394.
  • MSA prions exhibit remarkable stability and resistance to inactivation. Acta Neuropathol. 2018 01; 135(1):49-63. Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB. PMID: 28849371.
  • Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proc Natl Acad Sci U S A. 2016 11 29; 113(48):E7701-E7709. Hill SJ, Mordes DA, Cameron LA, Neuberg DS, Landini S, Eggan K, Livingston DM. PMID: 27849576.
  • Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging. Nat Commun. 2016 10 31; 7:13283. Tian F, Yang W, Mordes DA, Wang JY, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu FK, Ji M, Zhang R, Liu Y, Strominger J, Shneider NA, Petrucelli L, Xie XS, Eggan K. PMID: 27796305.
  • Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016 07 13; 8(347):347ra93. Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K. PMID: 27412785.
  • A 34-Year-Old Male with An Intracranial Mass. Brain Pathol. 2016 Mar; 26(2):289-90. LaBuzetta JN, Mordes D, Arrillaga I, Chi A, Dietrich J. PMID: 27000488.
  • Pigmented Lesions of the Nervous System and the Neural Crest: Lessons From Embryology. Neurosurgery. 2016 Jan; 78(1):142-55. Agarwalla PK, Koch MJ, Mordes DA, Codd PJ, Coumans JV. PMID: 26355366.
  • Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Sci Rep. 2015 Nov 13; 5:16622. Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. PMID: 26564777.
  • Case Records of the Massachusetts General Hospital. Case 30-2015: A 50-Year-Old Man with Cardiogenic Shock. N Engl J Med. 2015 Sep 24; 373(13):1251-61. Wheeler TM, Baker JN, Chad DA, Zilinski JL, Verzosa S, Mordes DA. PMID: 26398074.
  • Evidence for a-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):E5308-17. Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. PMID: 26324905.
  • Propagation of prions causing synucleinopathies in cultured cells. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):E4949-58. Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB. PMID: 26286986.
  • Case records of the Massachusetts General Hospital. Case 12-2015. A newborn boy with respiratory distress, lethargy, and hypernatremia. N Engl J Med. 2015 Apr 16; 372(16):1550-62. Lin TY, Ebb DH, Boepple PA, Thiele EA, Rincon SP, Mordes DA. PMID: 25875261.
  • VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations. Am J Clin Pathol. 2014 Jun; 141(6):811-5. Mordes DA, Lynch K, Campbell S, Dias-Santagata D, Nose V, Louis DN, Hoang MP. PMID: 24838325.
  • Intracranial organizing hematoma with papillary endothelial hyperplasia features after resection and involved field radiotherapy for cerebellar juvenile pilocytic astrocytoma. Clin Imaging. 2014 May-Jun; 38(3):322-5. Ginat DT, Walcott BP, Mordes D, Schaefer PW, Nahed B. PMID: 24456989.
  • Glioblastoma mimicking an arteriovenous malformation. Front Neurol. 2013; 4:144. Khanna A, Venteicher AS, Walcott BP, Kahle KT, Mordes DA, William CM, Ghogawala Z, Ogilvy CS. PMID: 24137154.
  • Cytopathology of subacute thyroiditis. Diagn Cytopathol. 2012 May; 40(5):433-4. Mordes DA, Brachtel EF. PMID: 22045514.
  • A workshop on leadership for MD/PhD students. Med Educ Online. 2011; 16. Ciampa EJ, Hunt AA, Arneson KO, Mordes DA, Oldham WM, Vin Woo K, Owens DA, Cannon MD, Dermody TS. PMID: 21841905.
  • In vitro fluid dynamics of the Ahmed glaucoma valve modified with expanded polytetrafluoroethylene. Curr Eye Res. 2011 Feb; 36(2):112-7. DeCroos FC, Kondo Y, Mordes D, Lee MR, Ahmad S, Asrani S, Allingham RR, Olbrich KC, Klitzman B. PMID: 21281065.
  • Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve. Curr Eye Res. 2009 Jul; 34(7):562-7. DeCroos FC, Ahmad S, Kondo Y, Chow J, Mordes D, Lee MR, Asrani S, Allingham RR, Olbrich KC, Klitzman B. PMID: 19899969.
  • Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18730-4. Mordes DA, Nam EA, Cortez D. PMID: 19028869.
  • The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol Cell Biol. 2008 Dec; 28(24):7345-53. Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D. PMID: 18936170.
  • Activation of ATR and related PIKKs. Cell Cycle. 2008 Sep 15; 7(18):2809-12. Mordes DA, Cortez D. PMID: 18769153.
  • TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 2008 Jun 01; 22(11):1478-89. Mordes DA, Glick GG, Zhao R, Cortez D. PMID: 18519640.
  • Identification of photoreceptor genes affected by PRPF31 mutations associated with autosomal dominant retinitis pigmentosa. Neurobiol Dis. 2007 May; 26(2):291-300. Mordes D, Yuan L, Xu L, Kawada M, Molday RS, Wu JY. PMID: 17350276.
  • Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol. 2007 May; 27(9):3367-77. Ball HL, Ehrhardt MR, Mordes DA, Glick GG, Chazin WJ, Cortez D. PMID: 17339343.
  • Pre-mRNA splicing and retinitis pigmentosa. Mol Vis. 2006 Oct 26; 12:1259-71. Mordes D, Luo X, Kar A, Kuo D, Xu L, Fushimi K, Yu G, Sternberg P, Wu JY. PMID: 17110909.
Awards
  • 2019 - 2024 NINDS Mentored Clinical-Scientist Research Career Development Award (K08)
  • 2017 - 2018 ADRC Massachusetts Alzheimer’s Disease Center, Pilot Project Award
  • 2015 ALS Association Investigator-Initiated Starter Grant
  • 2015 National Academy of Sciences, Cozzarelli Prize (with Prusiner lab) for top biomedical sciences publication in PNAS
  • 2010 Vanderbilt University, Dean’s Award for Research
  • 2009 Vanderbilt University, Alpha Omega Alpha
  • 2008 Leon W. Cunningham Graduate Biochemistry Award
  • 2008 Young Investigator Award, International