Ari B. Molofsky, MD, PhD
- UCSF Diabetes Center, UCSF Biomedical Sciences Graduate Program, UCSF Immunology Program
Our laboratory goals are to understand the function and regulation of tissue resident lymphocytes in settings of tissue development, remodeling, infection, and pathology, while providing a strong and supportive environment for our research trainees. By understanding the physiologic roles of tissue-resident immune cells and their regulation, we hope to define novel pathways that can be targeted in diverse human disease, including obesity/type 2 diabetes, allergic pathologies (asthma, allergy, atopic dermatitis), and neuropsychiatric disease. We are focused on type-2 immune-associated lymphocytes, including group 2 innate lymphoid cells (ILC2) and subsets of regulatory T (Treg) cells, and the stromal ‘niche’ signals involved in their regulation. These recently appreciated tissue resident cells are early organizers of tissue remodeling and first responders during tissue damage and infection, positioning them as key mediators of tissue health and disease.
- Dahlgren MW*, Jones SW*, Cautivo KM, Dubinin A, Farhat S, Ortiz-Carpena JF, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. Adventitial stromal cells define group 2 innate lymphoid cell tissue niches. Immunity, 2019, in press. *authors contributed equally
- Vainchtein, I.D*., Chin, G., Cho*, F.S., Kelley, K.W., Miller, J.G., Chien, E.C., Liddelow, S.A., Nguyen, P.T., Nakao-Inoue, H., Dorman, L.C., Akil, O., Joshita, S., Barres, B.A., Paz, J.T., Molofsky, A.B.#, Molofsky, A.V.#, 2018. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science 85. #Co-corresponding authors
- Molofsky, A.B., Van Gool, F., Liang, H.-E., Van Dyken, S.J., Nussbaum, J.C., Lee, J., Bluestone, J.A., and Locksley, R.M. (2015). Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity 43, 1-14.
- Molofsky, A. B., Nussbaum, J. C., Liang, H.-E., Van Dyken, S. J., Cheng, L. E., Mohapatra, A., Chawla, A., Locksley R.M. (2013). Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. Journal of Experimental Medicine, 210(3), 535–549.
- Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-Gonzalez, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., Locksley, R.M. (2011). Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science, 332(6026), 243–247.
- 2019 Nina Ireland Program for Lung Health Junior Investigator Award
- 2017 Milstein Young Investigator Award, International Cytokine & Interferon Society
- 2017 New Frontiers Research Awardee, UCSF Program for Breakthrough Biomedical Research
- 2016-2019 Larry L. Hillblom Foundation Junior Investigator Award
- 2017, 2019 American Association of Immunology, Travel Award
- 2014-2019 NIH K08 Clinical Scientist Career Development Award
- 2006 Alpha Omega Alpha (AOA) Medical Honors Society, University of Michigan
- 2006 Ward J. MacNeal Distinguished Dissertation Award, Microbiology/Immunology
- 1999 The Dean's Honored Graduate in Molecular Biology, University of Texas
- 1999 Phi Beta Kappa, University of Texas