Alan H.B. Wu, PhD

Alan H.B. Wu, PhD

Professor Laboratory Medicine; Chief, Clinical Chemistry Laboratory, SFGH; Chief, Clinical Pharmacogenomics Laboratory, UCSF
Laboratory Medicine
Clinical Chemistry
Specialty Areas
Cardiac Biomarkers
Analytical and Toxicology

Zuckerberg San Francisco General Hospital
1001 Potrero Avenue, Room 2M27
San Francisco, CA 94110
United States

Hospital Affiliations
Zuckerberg San Francisco General Hospital
Other UCSF Organizational Association(s)

Graduate faculty

  • Pharmaceutical Science and Pharmacogenomics
Research and Clinical Interests

Alan H.B. Wu, Ph.D., is Chief of Clinical Chemistry and Toxicology at San Francisco General Hospital Professor of Lab Medicine, University of California, San Francisco.  He received B.S. degrees in chemistry and biology at Purdue University and a Ph.D. degree in analytical chemistry at the University of Illinois.  He completed a postdoctoral fellowship in clinical chemistry at Hartford Hospital.  He is certified by the American Board of Clinical Chemistry in Clinical Chemistry and Toxicological Chemistry. His research interests include clinical toxicology, cardiac biomarkers, and point-of-care testing.  Dr. Wu has over 500 publications in peer-reviewed journals.  He has also written eight paperback books consisting of short stories designed to promote the value of the clinical laboratory to the general public.

Selected Publications
  • Lynch KL, Zhou S, Kaul R, Wu AHB. Evaluation of neutralizing antibodies against SARS-CoV-2 variants after infection and vaccination using a multiplexed surrogate virus neutralization test. Clin Chem 2021, doi: 10.1093/clinchem/hvab283
  • Thakkar AB, Ma Y, Dela Cruz M, Wu Y, Arechiga V, Swaminathan S, Ganz P, Wu AHB, Scherzer R, Deeks S, Hsue PY.  Effect of HIV‐1 infection on angiopoietin 1 and 2 levels and measures of microvascular and macrovascular endothelial dysfunction. J Am Heart Assoc 2021;10:
  • Jitto T, Wu AHB, Biswall S, Burman A, Shantanu P, Sengupta P. Development and preliminary validation of an infrared spectroscopic device for transdermal assessment of elevated cardiac troponin I.  Nature Biotechnol 2022:
  • Wu AHB, Wang CC, Lynch KL. Adequate antibody response to COVID-19 vaccine in patients with a monoclonal gammopathies, multiple myeloma, and amyloidosis. Lab Med 2022.  DOI: 10.1093/labmed/lmab113
  • Horiuchi Y, Wettersten N,  Patel MP, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander KE, Apple FS,  Cannon CM, Nagurney JT, Schreiber D, deFilippi C, Hogan, Diercks DB, Headden G, Limkakeng AT, Anand, Wu AHB, et al. Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome. Cor Art Dis 2022;33:576-84.
  • Silverstein A, Dudaev A, Studneva M, Aitken J, Blokh S, Miller AD, Tanasov S, Rose N, Ryals J, Borchers C, Nordstrom A, Moiseyakh M, Herrera AS, Skomorohov N, Marshall T, Wu A, et al.  Evolution of biomarker research in autoimmunity conditions for health professionals and clinical practice. Prog Mol Biol Transl Sci 2022,
  • Prahl M, Gola Y, Cassidy A, Matsui Y, Li L, Alvarenga B, Chen H, Jigmeddagva U, Gonzalez V, Chidboy M, Warrier L, Buarpung S, Murtha A, Flaherman V, Greene W, Wu A, Lynch K, Rajan J, Gaw S. Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy. Nat Comm 2022;14:4422.
  • Mudan A, Lebin JA, Wu AHB, Livshits Z.  Serum iron concentrations in non-iron induced acute liver injury. Clin Chim Acta 2022; 525:12-14.
  • Zhang Y, Tangsombatvisit C, Yun C, Pang S, Hooshfar S, Wu AHB, Lynch KL.  A high-resolution mass spectrometry method for the detection of fentanyl analogs. J Mass Spec Adv Clin Lab 2022; doi: 10.1016/j.jmsacl.2022.07.005
  • Baudhuin LM, Train LJ, Goodman SG, Lane GE, Lennon RJ, Mathew V, Murthy V, Nazif TM, So DYF, Sweeney JP, Wu AHB, Rihal CS, Farokoug ME, Pereira NL. Point of care CYP2C19 genotyping after percutaneous coronary intervention. Pharm J 2022,
  • 2002 American Assoc for Clinical Chemistry Outstanding Contributions to Education Award
  • 2005 IVD Technology's Top Ten Persons in the IVD Industry
  • 2005 AACC Connecticut Valley Section, Seligson-Golden Award
  • 2006 Meyer Bodanski Visiting Professor of Pathology, University of Texas Medical Branch
Additional Information