Stephanie E. Siegmund, MD, PhD
Assistant Professor
Pathology
Division
Surgical Pathology; Clinical Cancer Genomics Laboratory
Specialty Areas
Genitourinary Pathology & Molecular Pathology
UCSF
Pathology, Box 4066
1825 4th Street, Room M2371
San Francisco, CA 94158
United States
Hospital Affiliations
UCSF Parnassus Heights
UCSF Mission Bay
UCSF Mount Zion
Research and Clinical Interests
I am both a molecular pathologist and a surgical pathologist specialized in neoplastic disease of the genitourinary (GU) tract including prostate, urinary bladder, kidney, penis, and testis. My primary research interest lies in the application of molecular diagnostics to GU pathology, particularly for the characterization of testicular and renal tumors.
Selected Publications
- Akgul M, George RS, Siegmund SE, Oktay M, Sangoi AR, Williamson SR, Cheng L. Molecularly defined renal cell carcinomas: practical approaches for surgical pathologists. Histopathology. 2026 Jan;88(1):137-148. doi: 10.1111/his.70039. PMID: 41384685.
- Luu BE, Siegmund SE. Human Papillomavirus-Associated Penile Squamous Cell Carcinoma With Acquired p16 Null Immunophenotype. Mod Pathol. 2025 Sep;38(9):100846. doi: 10.1016/j.modpat.2025.100846. Epub 2025 Aug 6. PMID: 40774062.
- Zhao T, Akgul M, Siegmund SE. Clinicopathologic, immunohistochemical and genomic characterization of urothelial carcinoma with myxoid and chordoid features. Histopathology. 2025 Nov;87(5):757-767. doi: 10.1111/his.15545. Epub 2025 Aug 27. PMID: 40864529.
- Siegmund SE, Acosta AM. Somatic-type Malignancies of Germ Cell Origin: Molecular, Pathologic, and Clinical Features. Surg Pathol Clin. 2025 Mar;18(1):101-117. doi: 10.1016/j.path.2024.08.010. Epub 2024 Dec 3. PMID: 39890298.
- Siegmund S, Ricci C, Kao CS, Sangoi AR, Mohanty S, Fletcher CDM, Colecchia M, Acosta AM. Germline APC Alterations May Predispose to Testicular Sex Cord-Stromal Tumors. Am J Surg Pathol. 2023 Dec 1;47(12):1432-1437. doi: 10.1097/PAS.0000000000002132. Epub 2023 Oct 9. PMID: 37811860.
- Siegmund SE, Al-Obaidy KI, Tsai HK, Idrees MT, Akgul M, Acosta AM, Hirsch MS. Concordance of MTOR Pathway Mutations and the Diagnosis of Renal Low-Grade Oncocytic Tumor (LOT). Int J Surg Pathol. 2024 Apr;32(2):316-330. doi: 10.1177/10668969231178032. Epub 2023 Jun 26. PMID: 37357748.
- Siegmund SE, Sholl LM, Tsai HK, Yang Y, Vasudevaraja V, Tran I, Snuderl M, Fletcher CDM, Cornejo KM, Idrees MT, Al-Obaidy KI, Collins K, Gordetsky JB, Wobker SE, Hirsch MS, Trpkov K, Yilmaz A, Anderson WJ, Quiroga-Garza G, Magi-Galluzzi C, Canete-Portillo S, Acosta AM. Clinicopathologic and molecular spectrum of testicular sex cord-stromal tumors not amenable to specific histopathologic subclassification. Mod Pathol. 2022 Dec;35(12):1944-1954. doi: 10.1038/s41379-022-01155-y. Epub 2022 Sep 30. PMID: 36180576.
- Siegmund SE, Mehra R, Acosta AM. An update on diagnostic tissue-based biomarkers in testicular tumors. Hum Pathol. 2023 Mar;133:32-55. doi: 10.1016/j.humpath.2022.07.020. Epub 2022 Aug 3. PMID: 35932825.