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Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

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CREATININE CLEARANCE

Item Value
Available Stat? No
Test code CCLR
Performed by? Chemistry
Sendout? no
Price range $$
In House Availability 7 days
Interpretation Low creatinine clearance indicates decreased glomerular filtration as with decreased renal plasma flow (prerenal), glomerulonephritis, and obstructive nephropathies. Kidney injury, as with shock and drugs (aminoglycosides, mercurials, amphotericin, and others) will decrease creatinine clearance.
Container type gel tube
Amount to Collect 3 mL
Collection Instructions Refrigerate urine during collection.

Serum should be collected within 24 hours of urine specimen.
Sample type Clotted Blood
Special instructions Start 12- or 24-hour urine collection on the evening prior to drawing of blood sample. At the end of the 12- or 24-hour urine collection, draw blood specimen for creatinine. Send BOTH urine and blood to the lab. Patient's height and weight (inches, pounds) MUST accompany specimens, so correction of creatinine clearance to 1.73 m2 can be calculated.


Creatinine clearance mL/min (mL/s) = (Ucr/Scr)  x  (V/1440)  x (1.73/A) 

Ucr  = Concentration of creatinine in urine in mg/dL (micro mol/L)
Scr  = Concentration of creatinine in serum in mg/dL (micro mol/L)
V   = Volume of urine flow in mL/min (mL/s)

mL/min = ( V/1440 min/24 hours)          

A  = Body surface area in square meters

Normal range
Adult: 90-130 mL/min/1.73 m2 (0.87-1.25 mL/s/m2)
Infant: 40-65 mL/min/1.73 m2 (0.38-0.63 mL/s/ m2).

Additional information INDICATIONS: Monitor renal function (glomerular filtration rate).
References 1. Bayer(TM) Clinical Methods Creatinine (12) B01-4126-01 Advia 1650 Operator's Guide. PN 073-5001-09. Last accessed June 2003. Siemens Medical Solutions Diagnostics, Malvern, PA.

2. Duarte, CG and Preuss, HG. Assessment of Renal Function: Glomerular and Tubular. Clin Lab Med. 1993. 13:33-52.

3. Lake, DR et al.: Validity of Creatinine Clearance Estimates in the Assessment of Renal Function. Clin Pharmacol Ther. 1990. 48:503-8.

4. Van Lente, F and Suit, P. Assessment of Renal Function by Serum Creatinine and Creatinine Clearance: Glomerular Filtration Estimated by Four Procedures. Clin Chem. 1989. 35: 2326-30.
CPT coding 82575
Last Updated 6/13/2013 11:08:50 AM
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