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Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

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CREATININE, SERUM, PLASMA, FLUID

Item Value
Available Stat? Yes
Test code CREA, FCRE
Performed by? Chemistry
Sendout? no
Price range $
In House Availability Routine: 7 days, routine hours.
STAT: 24 hours/7 days.
Principle The Siemens ADVIA 1800 assay is an enzymatic creatininase method. The calibration is traceable to SRM967 and correlated with the NIST LC-IDMS method.
Interpretation Serum creatinine is not a sensitive indicator of early renal disease.

1. Creatinine elevated: impaired renal (glomerular) function, pre- and post-renal azotemia, certain muscle diseases (polymyositis, muscular dystrophy), muscle crush, intramuscular injections, exercise, and excessive growth hormone. Ingestion of creatinine (roast meat).

2. A 10:1 ratio of BUN:creatinine is seen in excess intake of protein, blood in the small bowel, excess tissue breakdown (cachexia, burns, high fever, corticosteroid therapy), urinary tract obstruction (post-renal), CHF (dehydration, shock), and with excessive urinary reabsorption (ureterocolostomy). A ratio of less than 10:1, BUN:creatinine, is seen in low protein intake, repeated dialysis, severe diarrhea or vomiting, and hepatic insufficiency.
Container type gel tube (gold or green top).
Amount to Collect 2 mL
Sample type Blood
Normal range
Age Female
(mg/dL)
Male
(mg/dL)
90 0.50-1.30 0.70-1.70
18 0.50-1.10 0.70-1.30
12 0.50-1.00 0.50-1.00
2 0.30-0.70 0.30-0.70
0 0.20-0.40 0.20-0.40
Synonyms Metabolic Basic Panel (METB): NA, K, CL, CO2, CREA, BUN, GLUC, CA;
Stability Stored at 4°C, stable 24 hours; frozen, 6 months.
Interferences Blood samples from some patients with disease states where significantly elevated immunoglobulin levels occur may have falsely elevated results when using this assay.
Additional information INDICATIONS: Assessment of glomerular function (in conjunction with BUN) and severe muscular function abnormalities.
References 1. Chasson, A.L., Grady, H.T., Stanely, M.A.: Am J Clin Pathol, 35:83, 1961.

2. Young, DS, Effect of Drugs on Clinical Laboratory Tests. 4th Edition: AACC Press; Washington DC, 1995.
CPT coding 82570
Last Updated 7/24/2015 5:39:39 PM
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