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Lab Manual for UCSF Clinical Laboratories

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C-REACTIVE PROTEIN, HIGH SENSITIVITY

Item Value
Available Stat? Yes
Test code CRPH
Performed by? Chemistry
Sendout? no
Price range $$
In House Availability Stat or routine, 24 hours/7 days
Principle Latex enhanced immunoturbidimetric
Interpretation In most normal individuals, CRP is an acute-phase protein that is present in serum and plasma in very low concentrations. CRP serum concentrations become elevated in response to many pathological conditions, including infection, tissue injury, inflammatory disorders, and associated diseases. Increases in CRP values are non-specific for many disease processes, and should not be interpreted without a complete clinical evaluation.

Studies have shown that measurement of CRP by high sensitivity assays is a strong independent predictor of risk for future cardiovascular and peripheral vascular disease. [2,3] High sensitivity CRP measurements have also been shown to add to the predictive value of other markers used to assess the risk of cardiovascular and peripheral vascular disease. [3,4] Elevated CRP values determined by high sensitivity CRP assays may be indicative of the prognosis of individuals with acute coronary syndromes, and may be useful in the managment of such individuals.
Container type gel tube (gold or green top)
Amount to Collect 2 mL
Sample type Blood
Normal range Cardiovascular Disease Risk:

Tertile hsCRP mg/L Cardiovascular risk
1 < 1.0 Low
2 1.0-3.0 Moderate
3 3.1-10.0 High


Non-Cardiovascular Inflammation:
> 10 mg/L


Synonyms CRP;
Stability Analyze fresh or store at refrigerated temperature.
8 hours @ RT
3 days at 2-8°C
6 months at -20°C
References 1. Ng PC, Cheng SH, Chiu KM, et al. Diagnosis of the late onset neonatal sepsis with cytokines, adhesion molecule and C-reactive protein in preterm very low birthweight infants. Arch Dis Child Fetal Neonata Ed. 1997 Nov; 77(3):F221-7.

2. Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular diseases; application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003; 107:499-511.

3. Tracy RP, Lemaitre RN, Psaty BM, et al. Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion project. Arterioscler Thromb Basc Biol 1997; 17:1121-7.

4. Ricker PM, Stampfer MJ, Rifai N. Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein, and standard cholesterol screening as predictors of peripheral arterial disease. JAMA 2001; 285:2481-5.
CPT coding 86141
Last Updated 6/11/2013 4:00:36 PM
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