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Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

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BENZODIAZEPINES, URINE

Item Value
Available Stat? Yes
Test code BENZ
Performed by? Chemistry
Sendout? no
Price range $$
In House Availability Routine or Stat: 24 hours 7 days
Principle Competitive immunoassay using CEDIA technology.
Interpretation CLINICAL SIGNIFICANCE: The benzodiazepines are a family of drugs that have sedatives and anti-anxiety properties. These drugs are also used to prevent seizures.

Cutoff: 200 ng/mL.

Drug Detection Period (approximate guideline) = Up to two weeks.

Positive results are not confirmed. Drugs detected include: alprazolam (Xanax) and metabolites, clonazepam (Klonopin, Rivotril) and metabolites, diazepam (Valium) and metabolites nordiazepam and oxazepam, flurazepam (Dalmane) and metabolites, lorazepam and metabolite (Ativan), nitrazepam (Mogadon), oxazepam (Serax), temazepam (Restoril), and triazolam (Halcion).

This assay, unlike most other benzodiazepine immunoassays, will detect certain benzodiazepines that are excreted primarily as glucuronide metabolites (e.g. lorazepam excreted as lorazepam glucuronide). This assay does not detect atypical benzodiazepine receptor ligands such as eszopiclone (Lunesta), zaleplon (Sonata) and zolpidem (Ambien).
Amount to Collect 10 mL
Sample type Urine
Normal range Negative
Stability Minimum 1 week at 2-8°C.
Turn around times Screening results are reported within 1 to 8 hours.
References Wu AHB, Broussard LA, Hoffman RS, Kwong TC, McKay C, Moyer TP, Otten EM, Welch SL, Wax P. National Academy of Clinical Biochemistry. Laboratory Medicine Practice Guidelines. Recommendations for the Use of Laboratory Tests to Support the Impaired and Overdosed Patients from the Emergency Department. Clin Chem 2003; 49:357-79.
CPT coding 80101
Last Updated 10/24/2012 8:48:10 AM
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