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Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

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VALPROIC ACID

Item Value
Available Stat? No
Test code VPA
Performed by? Chemistry
Sendout? no
Price range $$$
In House Availability Routine: 7 days;
STAT: 24 hours/ 7 days
Principle The Siemens Centaur assay is a competitive immunoassay using direct chemiluminescent technology.
Interpretation Valproic Acid is a broad spectrum anticonvulsant drug used for the effective treatment of seizures. This drug is especially effective in the treatment of many types of seizures in children in whom tonic-clonic and myoclonic seizures are most prevalent. Serum measurement of valproic acid is necessary for monitoring blood level of drugs to achieve effective therapy.
Container type gold top gel tube
Amount to Collect 2 mL
Collection Instructions Plasma samples will not be analyzed.
Sample type Blood
Normal range The optimal therapeutic range is 50-100 mg/L (347-693 mcmol/L). All values greater than 150 mg/L (1040 mcmol/L) are considered Critical Values and are called to the doctor or patient care unit immediately.
Stability After centrifugation, the specimen is stable for 48 hours at 2-8°C.
Interferences 1. Auto- (rheumatoid factor) and heterophile antibodies in human serum can react with reagent immunoglobulins, interfering with in vitro immunoassays. Patients routinely exposed to animals or to animal serum products can be prone to this interference. Anomalous values, spuriously low or high, may be observed. Results inconsistent with clinical findings or previous laboratory values can be investigated by the laboratory for this phenomenon. Call the Clinical Chemistry Laboratory Medicine Resident (x65527, pager 415-443-2311).
References 1. Penry, J.K. and Newmark, M.E.: Ann Int Med 90:207, 1979.

2. Bayer 129198 Rev. A, 2002-03. Siemens Medical Solutions Diagnostics, Malvern, PA.
CPT coding 80164
Last Updated 6/18/2011 8:19:24 AM
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