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RETICULOCYTE HEMOGLOBIN CONTENT (CHR)

Item Value
Approval req'd? no
Available Stat? No
Test code CHR
Performed by? Hematology
Sendout? no
Price range $$
In House Availability 24 hours/ 7 days
Principle Measured by flow cytometry on the Advia 2120 hematology analyzer.
Interpretation INTERPRETATION: CHR represents the hemoglobin content in reticulocytes, the youngest red blood cells (RBC) which transition to mature RBC in 1 to 2 days.

CLINICAL SIGNIFICANCE: CHR is helpful in identifying iron deficiency states, including "functional" iron deficiency earlier than traditional tests for this condition. Specifically, CHR has been found useful in screening infants 9-12 months for iron deficiency anemia and in monitoring patient response to iron and erythropoietin therapies in hemodialysis patients.
Container type EDTA (lavender top) tube
Amount to Collect 4 mL
Sample type EDTA Whole blood
Normal range
Age Male (pg/cell) Female (pg/cell)
1 day - < 2 years 22.5 – 31.8 23.9 – 30.9
2 years - < 6 years 25.1 – 32.0 26.4 – 32.1
6 years - < 12 years 23.6 – 33.9 25.1 – 33.3
12 years - < 18 years 27.0 – 33.2 28.2 – 33.9
18 years and older 30.1 – 34.6 27.1 – 35.2

Stability Stable for 24 hours if stored at 20-30°C.
References 1. Ullrich et al. JAMA 2005; 294:924-930

2. Fishbane et al. Kidney Int 2001: 60:2406-2411

3. Soldin et al. Pediatric Reference Intervals, 5th ed. AACC Press Washington, DC 2003
CPT coding 85046
Last Updated 3/7/2012 3:05:42 PM
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