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Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

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FIBRINOGEN DETERMINATION, QUANTITATIVE

Item Value
Approval req'd? no
Available Stat? Yes
Test code FIBR
Performed by? Hematology
Sendout? no
Price range $$
In House Availability Stat or routine, 24 hours/7days
Principle Fibrinogen is converted to fibrin using l00 U/mL of thrombin. The rate of conversion is inversely proportional to the concentration of functional fibrinogen in the test plasma (based on the method by Clauss).
Interpretation A deficiency in functional fibrinogen (hypofibrinogenemia, dysfibrinogenemia, afibrinoginemia) may be congenital or acquired (i.e., by failure or alteration of synthesis, intravascular coagulation, or fibrinolytic disorders).
Container type citrate blue top tube
Amount to Collect Full tube (2.7 mL blood, pediatric: 1.8 mL)
Collection Instructions See Coagulation Procedures for instructions on collecting coagulation specimens.
Sample type citrated plasma
Special instructions Indicate use of anticoagulant drugs on requisition slip.
Normal range 170-440 mg/dL
Additional information To investigate abnormal PT, APTT, and TT, and to screen for disseminated intravascular coagulation (DIC) and/or fibrin fibrinogenolysis.
References Clauss, A. Acta Haemat, 17:237, 1957.
CPT coding 85384
Last Updated 9/30/2010 10:43:08 AM
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