Zachary Mackey
Education:
1994-2000: Ph.D. University of Texas Health Science Center
at San Antonio Department of Molecular Medicine.
1984-1989: B.S. University of Nebraska-Lincoln

Professional Experience:
1992-1993: Research Assistant, University of Texas Health Science
Center at San Antonio Institute of Biotechnology.

1990-1992: Research Assistant, Virus Reference Laboratory Inc.
San Antonio, Texas

Grants and Awards:
2000 2002: UNCF-Merck Postdoctoral Fellowship Award

1997-1999: UNCF-Merck Graduate Science Research Dissertation
Fellowship Award.

1996-1997: Howard Hughes Medical Institute Enrichment Program for a
Minority Trainee Supplement.

1994-1996: (DAMD17-94-J-4147) Training Program in Molecular Basis
of Breast Cancer from the Department of the Army.

Research Articles:
Alan E. Tomkinson, Ling Chen, Zhiwan Dong, John B. Leppard, David S. Levine,
Zachary B. Mackey and Teresa A. Motycka. Completion of Base Excision Repair by Mammalian DNA Ligases. Progress in Nucleic Acid Research and Molecular Biology, Vol. 68: 157-164 (In Press)

Mackey ZB, Neidregang C, de Murcia JM, Leppard J, Au K, Chen J, de Murcia G,
Tomkinson AE, DNA Ligase III is recruited to DNA strand breaks by a zinc finger motif
homologous to that of poly (ADP-ribose) polymerase: Identification of two functionally
distinct DNA binding regions within DNA ligase III. J Biol Chem. 274(31):21679-21687, 1999 July 31.

Chen J. Tomkinson AE. Ramos W. Mackey ZB. Danehower S. Walter CA.
Schultz RA. Besterman JM. Husain I. Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. Mol Cell Biol. 15(10):5412-22, 1995 Oct.

Tomkinson AE. Mackey ZB. Structure and function of mammalian DNA ligases. Mutat Res. 407(1):1-9, 1998 Feb.

Mackey ZB. Ramos W. Levin DS. Walter CA. McCarrey JR. Tomkinson AE.
An alternative splicing event ,which occurs in mouse pachytene spermatocytes, generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination. Mol Cell Biol. 17(2):989-98, 1997 Feb.

Kamel D. Mackey ZB. Sjoblom T. Walter CA. McCarrey JR. Uitto L.
Palosaari H. Lahdetie J. Tomkinson AE. Syvaoja JE. Role of deoxyribonucleic acid polymerase epsilon in spermatogenesis in mice. Biol Reprod. 57(6):1367-74, 1997 Dec.

Husain I. Tomkinson AE. Burkhart WA. Moyer MB. Ramos W. Mackey ZB.
Besterman JM. Chen J. Purification and characterization of DNA ligase III from bovine testes. Homology with DNA ligase II and vaccinia DNA ligase. J Biol Chem. 270(16):9683-90, 1995 Apr 21.

Wang YC. Burkhart WA. Mackey ZB. Moyer MB. Ramos W. Husain I. Chen J.
Besterman JM. Tomkinson AE. Mammalian DNA ligase II is highly homologous with vaccinia DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation. J Biol Chem. 269(50):31923-8, 1994 Dec 16.

Zachary B. Mackey UNCF/Merck Postdoctoral Science Research Fellowship Applicant