Item Value
Test name Voriconazole
Available Stat? No
Turn around times 3-4 days
In House Availability Tuesday and Friday AM (excluding holidays)
Performed by China Basin Chemistry
Normal range Achievable steady state levels with typical dosing range from 2.0-6.0 µg/mL.

Serum trough levels of ≤ 1.0 µg/mL are reported to be associated with lack of therapeutic response.
Serum trough levels of > 6.0 µg/mL have been reported to be associated with reversible neurological adverse events and hepatotoxicity.

References:
Hamada et al. Practice Guidelines for therapeutic drug monitoring of voriconazole: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring. Journal of Infection and Chemotherapy. 2013; 19(3): 381-392.

Pascual et al. Challenging recommended oral and intravenous voriconazole doses for improved efficacy and safety: Population pharmacokinetics-based analysis of adult patients with invasive fungal infections. Clinical Infectious Diseases. 2012; 55(3): 381-390.
Container type Red top tube (Gold top NOT acceptable)

Note: UCSF does not offer CSF testing. If required this can be ordered as a MOLT test from Quest.
Amount to Collect
Blood 2 mL
Collection Instructions Collect trough levels just before next dose. Peak levels:
IV 15-30 minutes after end of infusion
IM 45-60 minutes after injection
PO 90 minutes after ingestion
Sample type Serum

If you have additional questions regarding this test, please call: 415-353-1667