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Uric Acid, Plasma / Serum, Rasburicase Therapy

Item Value
Available Stat? No
Test code URICR
Performed by Parnassus, Mission Bay & Mount Zion Chemistry
In House Availability Test available 24 hours per day 7 days per week
Method Spectrophotometric (Uricase)
Collection Instructions Deliver to lab immediately on ICE

It is recommended that this sample handling procedure for uric acid be followed for up to 4 days after the last dose of rasburicase is administered.
Container type Light green top (on ice) preferred, Gold top (on ice) acceptable.
Amount to Collect 1 mL blood
Click here for Microdetermination info
Sample type Plasma or serum
Preferred volume 0.5 mL plasma or serum
Min. Volume 0.2 mL plasma or serum
Click here for Microdetermination info
Processing notes Provide immediately to Chemistry at Parnassus, Mission Bay or Mt Zion who will centrifuge and assay sample.

If specimen cannot be run at either site centrifuge immediately. Aliquot and freeze the plasma (-20C) immediately and send immediately to other site for testing
Normal range
Age Male Female
< 1 month 1.2-3.9 mg/dL 1.0-4.6 mg/dL
1 month - 11 months 1.2-5.6 mg/dL 1.1-5.4 mg/dL
1 year - 3 years 2.1-5.6 mg/dL 1.8-5.0 mg/dL
4 years - 6 years 1.8-5.5 mg/dL 2.0-5.1 mg/dL
7 years - 9 years 1.8-5.4 mg/dL 1.8-5.4 mg/dL
10 years - 12 years 2.2-5.8 mg/dL 2.5-5.9 mg/dL
13 years - 15 years 3.1-7.0 mg/dL 2.2-6.4 mg/dL
16 years - 17 years 2.1-7.6 mg/dL 2.4-6.6 mg/dL
≥ 18 years 3.9-8.2 mg/dL 2.9-6.6 mg/dL


1. Pediatric reference ranges adopted from Soldin, Steven J. Pediatric Reference Intervals (method 3), 6th edition, AACC Press, 2007.
2. Normal range for adults was determined by testing 137 male and 129 female healthy blood donors at UCSF.
Synonyms Urate; Gout
Turn around times 4 hours
Additional information Severe hyperbilirubinemia may artifactually decrease the result.

To convert mg/dL to mmol/L (SI units) multiply by 0.059

For patients on rasburicase therapy, it is recommended that samples be sent to the laboratory on ice and maintained at 4C until analysis to minimize in vitro degradation of uric acid that can occur due to sample transport (Lim E, Bennett P, Beilby J, Clinical Chemistry 2003;49:1417-1419). Uric acid samples in patients on rasburicase therapy should also be centrifuged cold and be kept refrigerated at 4C until testing. It is recommended that this sample handling procedure for uric acid be followed for up to 4 days after the last dose of rasburicase is administered.

According to some sources, "Although serum urate (SU) levels < 8 mg/dl are generally considered to be normal, serum levels > 6.8 mg/dl are above saturation level and may allow deposition of gouty crystals. A SU level of approximately 6.8 mg/dl is the concentration at which monosodium urate crystals begin to precipitate." Based on these considerations, some authorities recommend that that a normal SU should be considered below 6.8 mg/dL (Schlesinger et al .J Rheumatol 2009;36:1287–9). During an acute gouty attack, as many as 14% of patients may have a SU ≤ 6 mg/dlL and 32% may have SU of ≤ 8 mg/dL. Thus, a "normal" SU by either definition does not exclude an acute gouty attack.
CPT coding 84550
LOINC code 3084-1
Last Updated 1/14/2016 9:43:02 AM
Entry Number 1646
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