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Accuratio Parathyroid Hormone

Item Value
Test Update Information Conventional "intact" PTH assays detect both 1-84 PTH and 7-84 PTH fragment. Both 1-84 PTH and 7-84 PTH are secreted by the parathyroid gland. According to the manufacturer of the Accuratio PTH assay (Scantibodies Clinical Laboratories), the Accuratio PTH assay can distinguish between 1-84 PTH and 7- 84 PTH. Functionally, 7-84 PTH may cause the body to do the opposite of 1-84 PTH with respect to serum calcium, osteoclast formation, bone resorption, bone turnover, and bone formation. Thus, 7-84 PTH may have an inverse biological activity compared to that of 1-84 PTH. 1-84 PTH activates adenylate cyclase and is termed by the manufacturer of the Accuratio PTH assay as Cyclase Activating PTH (CAPª) whereas 7-84 PTH does not activate adenylate cyclase and is termed Cyclase Inactive PTH (CIPª). The fact that 7-84 PTH does not activate adenylate cyclase is suggested by evidence that 7-84 PTH may operate through a PTH C-terminal receptor (that may not activate adenylate cyclase); whereas, 1-84 PTH operates through the classical PTH/PTHrp receptor that does signal through adenylate cyclase. The Accuratio PTH assay involves two assays: One of the assays detects both 1-84 PTH and 7-84 PTH and is similar to conventional "intact" PTH assays. A separate assay (CAPª) detects only 1-84 PTH. The result of the 1-84 PTH assay is subtracted from the result of the "intact" PTH assay that detects both 1-84 PTH and 7-84 PTH to calculate the 7-84 PTH (CIPª) value. The CAPª value (1-84 PTH) is divided by the CIPª value (7-84 PTH) to calculate the CAPª/CIPª ratio.
Available Stat? No
Test code MOLT
Performed by Performed by Scantibodies Clinical Labs via Mayo
Sendout? Yes
Container type Lavender top (EDTA)
Amount to Collect 6 mL blood
Sample type EDTA plasma
Preferred volume 3 mL EDTA plasma
Min. Volume 2 mL EDTA Plasma
UCSF Rejection Criteria Non-EDTA sample received
Processing notes Spin down and aliquot 3 mL of plasma and freeze at -20°C

Units pg/mL
Normal range
Total PTH Reference Range 14.0-66.0 pg/mL
Cyclase active PTH (CAP; 1-84 PTH) 5.0-39.0 pg/mL
Cyclase inactive PTH (CIP; 7-84 PTH) 2.5-29.0 pg/mL
CAP/CIP ratio 1.1-6.9
Synonyms Accuratio PTH
CPT coding 83970-90 x2
Last Updated 9/6/2017 3:00:24 PM
Entry Number 1631
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