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Vitamin B3

Item Value
Approval req'd? No
Available Stat? No
Test code VIB3
Performed by Quest
Sendout? Yes
Method LC/MS/MS
Container type Red top or Lavender top
Amount to Collect 4 mL blood
Sample type Serum or EDTA plasma
Preferred volume 2 mL serum or plasma
Min. Volume 1 mL serum or plasma
Processing notes Aliquot and freeze. Transport to CB frozen. Order Quest test code 91029.
Units ng/mL
Normal range Due to the large variability in the metabolism of nicotinic acid, the dosing preparation used (immediate-release vs. extended release), and the mg doses used, the serum concentrations may range from <20 ng/mL to about 30,000 ng/mL. After oral administration of an immediate-release tablet, peak plasma concentrations occur in 4 to 5 hours. The plasma half-life of nicotinic acid is about one hour. In one study, fasting plasma concentrations were reported to be <20 ng/mL. In another study, it was reported that the administration of a single 1000 mg extended-release tablet resulted in mean nicotinic acid concentrations of <50 ng/mL.

Nicotinamide is a metabolite of nicotinic acid. Due to the large variability in the metabolism of nicotinic acid, plasma concentrations of this metabolite are variable. In one study, fasting plasma concentrations were reported to be approximately 40 ng/mL. In another study it was reported that the administration of single 1000 mg of extended-release tablet of nicotinic acid resulted in a mean peak nicotinamide concentration of 400 ng/mL between 5 and 10 hours post dose, decreasing to about 100 ng/mL by 16 hours post dose.
Synonyms Niacin
Stability Frozen 1 month
Turn around times 2- 6 days
Additional information Nicotinic Acid occurs naturally in plants and animals and is also added to many foods as a vitamin supplement.
CPT coding 84591-90
Last Updated 7/6/2015 8:33:02 AM
Entry Number 1594
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