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Lab Manual for SFGH

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Item Value
ClinicalQuestion Does my patient have von Willebrand disease? If so, which type?
TestEntryNumber 362
TestCode F8
TestName Ristocetin Cofactor Activity
Synonyms vW Factor; ; von Willebrand factor activity; VWF activity
IsThisScreeningTest Yes
PubMedID PMID:18315614,11686101
NLMID:101518625,101539022
Comment - vWF binds to F8 and protects it from degradation in plasma
- F8 activity is decreased in many types of vWD and is complementary to vWF antigen levels
- ideally, ordered as part of von Willebrand panel (VWP, 1006)
Sensitivity complementary to VWFAG and RCOF
Specificity complementary to VWFAG and RCOF
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