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Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

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Item Value
ClinicalQuestion Does my patient have antiphospholipid syndrome (APLS)?
TestEntryNumber 1044
TestCode B2GPG
TestName Lupus Anticoagulant by HEXA
Synonyms LA; antiphospholipid AB; Anti-cardiolipin; HEXA; RVVT; Russel's viper venom; Hexagonal phospholipid neutralization
IsThisScreeningTest No
PubMedID 18755986, 16420554, 12393574, 22951216
Comment In the context of diagnosing anti-phospholipid syndrome, anti-beta-2-glycoprotein IgG and IgM should be performed in conjunction with other laboratory tests (all pertinent labs are included in the anti-phopholipid antibody panel) in patients who meet clinical criteria as defined in the revised Sapporo criteria (J Thromb Haemost. 2006;4(2):295). The laboratory evaluation should take place at least 12 weeks after a qualifying clinical event and be repeated at least 12 weeks after the first round of tests. We do not recommend testing for anti-phospholipid syndrome at the time of an acute event. The presence of clinical criteria and at least one positive laboratory criteria (with repeat positivity at least 12 weeks apart) establishes a diagnosis of anti-phospholipid syndrome.

Studies have shown that the association of thrombosis is strenghtened with high titers and IgG subtype of anti-beta-2-glycoprotein. Studies have shown that IgG or IgM anti-beta-2-glycoprotein demonstrate weaker association with thrombosis than a positive lupus anticoagulant test.

Anti-beta-2-glycoprotein is more specific than anti-cardiolipin.
Sensitivity NA
Specificity NA
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