PUBLICATIONS

 

2017

Loo, K., Tsai, K.K., Mahuron, K., Liu, J., Pauli, M.L., Sandoval, P.M., Nosrati, A., Lee, J., Chen, L., Hwang, J., Levine, L.S., Krummel, M.F., Algazi, A.P., Alvarado, M.D., Rosenblum, M.D., Daud, A.I. Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy. JCI Insight. 2017 Jul 20;2(14). pii: 93433. doi: 10.1172/jci.insight.93433. [Epub ahead of print]. [PDF]

Yipp, B.G., Kim, J.H., Lima, R., Zbytnuik, L.D., Petri, B., Swanlund, N., Ho, M., Szeto, V.G., Tak, T., Koenderman, L., Pickkers, P., Tool, A.T.J., Kuijpers, T.W., van den Berg, T.K., Looney, M.R., Krummel, M.F., Kubes, P. The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection. Sci Immunol. 2017 Apr 28;2(10). pii: eaam8929. doi: 10.1126/sciimmunol.aam8929. PMID: 28626833. [PDF]

Cai, E., Marchuk, K., Beemiller, P., Beppler, C., Rubashkin, M.G., Weaver, V.M., Gérard, A., Liu, T.L., Chen, B.C., Betzig, E., Bartumeus, F., Krummel, M.F.. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science. 2017 May 12;356(6338). pii: eaal3118. doi: 10.1126/science.aal3118. PMID: 28495700. [PDF]

Tumeh, P.C., Hellmann, M.D., Hamid, O., Tsai, K.K., Loo, K.L., Gubens, M.A., Rosenblum, M., Harview, C.L., Taube, J.M., Handle,y N., Khurana, N., Nosrati, A., Krummel, M.F., et al. Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC.Cancer Immunol Res. 2017 May;5(5):417-424. doi: 10.1158/2326-6066.CIR-16-0325. Epub 2017 Apr 14. PMID: 28411193. [PDF]

Lefrançais, E., Ortiz-Muñoz, G., Caudrillier, A., Mallavia, B., Liu, F., Sayah, D.M., Thornton, E.E., Headley, M.B., David, T., Coughlin, S.R., Krummel, M.F., Leavitt, A.D., Passegué, E., Looney, M.R. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 Apr 6;544(7648):105-109. doi: 10.1038/nature21706. Epub 2017 Mar 22. PMID: 28329764. [PDF]

Wong, P.T., Roberts, E.W., Tang, S., Mukherjee, J., Cannon, J., Nip, A.J., Corbin, K., Krummel, M.F., Choi, S.K. Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer. JACS Chem Biol. 2017 Feb 17. doi: 10.1021/acschembio.6b00999. [Epub ahead of print]. PMID: 28191924. [PDF]

 

2016

Chong, S.Z., Evrard, M., Devi, S., Chen, J., Lim, J.Y., See, P., Zhang, Y., Adrover, J.M., Lee, B., Tan, L., Li, J.L., Liong, K.H., Phua, C., Balachander, A., Boey, A., Liebl, D., Tan, S.M., Chan, J.K., Balabanian, K., Harris, J.E., Bianchini, M., Weber, C., Duchene, J., Lum, J., Poidinger, M., Chen, Q., Rénia, L., Wang, C.I., Larbi, A., Randolph, G.J., Weninger, W., Looney, M.R., Krummel, M.F., Biswas, S.K., Ginhoux, F., Hidalgo, A., Bachelerie, F., Ng, L.G. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med. 2016 Oct 17;213(11):2293-2314. PMCID: PMC5068243. [PDF]

Pinkard, H., Stuurman, N., Corbin, K., Vale, R., Krummel, M.F. Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy. Nat Methods. 2016 Sep 29;13(10):807-809. doi: 10.1038/nmeth.3991. No abstract available. PMCID: PMC5100821. [PDF]

Boldajipour, B., Nelson, A., Krummel, M.F. Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine. JCI Insight. 2016 Dec 8;1(20):e89289. PMCID: PMC5135268. [PDF]

Starobinets, H., Ye, J., Broz, M., Barry, K., Goldsmith, J., Marsh, T., Rostker, F., Krummel, M., Debnath, J. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016 Oct 24. pii: 85705. doi: 10.1172/JCI85705. [Epub ahead of print]. PMID: 27775547. [PDF]

Sen, D., Jones, S.M., Oswald, E.M., Pinkard, H., Corbin, K., Krummel, M.F. Tracking the Spatial and Functional Gradient of Monocyte-To-Macrophage Differentiation in Inflamed Lung. PLoS One. 2016 Oct 18;11(10):e0165064. doi: 10.1371/journal.pone.0165064. PMID: 27755611. [PDF]

Loyher, P.L., Rochefort, J., Baudesson de Chanville, C., Hamon, P., Lescaille, G., Bertolus, C., Guillot-Delost, M., Krummel, M., Lemoine, F.M., Combadière, C., Boissonnas, A.. CCR2 influences T regulatory cell migration to tumors and serves as a biomarker of cyclophosphamide sensitivity. Cancer Res. 2016 Sep 28. pii: canres.0984.2016. PMID: 27680685. [PDF]

Thanabalasuriar, A., Neupane, A.S., Wang, J., Krummel, M.F., Kubes, P. iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation. Cell Rep. 2016 Sep 20;16(12):3260-72. doi: 10.1016/j.celrep.2016.07.052. PMID: 27653688. [PDF]

Daud, A.I., Loo, K., Pauli, M.L., Sanchez-Rodriguez, R., Sandoval, P.M., Taravati, K., Tsai, K., Nosrati, A., Nardo, L., Alvarado, M.D., Algazi, A.P., Pampaloni, M.H., Lobach, I.V., Hwang, J., Pierce, R.H., Gratz, I.K., Krummel, M.F., Rosenblum, M.D. Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. J Clin Invest. 2016 Sep 1;126(9):3447-52. doi: 10.1172/JCI87324. PMCID: PMC5004965. [PDF]

Roberts, E.W., Broz, M.L., Binnewies ,M., Headley, M.B., Nelson, A.E., Wolf, D.M., Kaisho, T., Bogunovic, D., Bhardwaj, N., Krummel, M.F. Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. Cancer Cell. 2016 Aug 8;30(2):324-36. doi: 10.1016/j.ccell.2016.06.003. Epub 2016 Jul 14. PMID: 27424807.[PDF]

Jones, L.M., Broz, M.L., Ranger, J.J., Ozcelik, J., Ahn, R., Zuo, D., Ursini-Siegel, J., Hallett, M.T., Krummel, M., Muller, W.J. STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis. Cancer Res. 2016 Mar 15;76(6):1416-28. doi: 10.1158/0008-5472.CAN-15-2770. Epub 2015 Dec 30. PMID: 26719528. [PDF]

Pinkard, H., Corbin, K., Krummel, M.F. Spatiotemporal Rank Filtering Improves Image Quality Compared to Frame Averaging in 2-Photon Laser Scanning Microscopy.PLoS One. 2016 Mar 3;11(3):e0150430. doi: 10.1371/journal.pone.0150430. eCollection 2016. PMCID: PMC4777388. [PDF]

Krummel, M.F., Bartumeus, F., Gérard, A. T cell migration, search strategies and mechanisms. Nat Rev Immunol. 2016 Feb 8. doi: 10.1038/nri.2015.16. [Epub ahead of print]. PMID: 26852928. [PDF]

Headley, M.R., Bins, A., Nip, A., Roberts, E.W., Gerard, A., Krummel, M.F. Visualization of Immediate Immune Responses to Pioneer Metastatic Cells in the Lung. Nature. 2016 Mar 16. doi: 10.1038/nature16985. [Epub ahead of print]. PMID: 26982733. [PDF]

Mujal, A.M., Gilden, J.K., Gérard, A., Kinoshita, M., Krummel, M.F. A septin requirement differentiates autonomous and contact-facilitated T cell proliferation. Nat Immunol. 2016 Mar;17(3):315-22. doi: 10.1038/ni.3330. Epub 2015 Dec 21. PMCID: PMC4755847. [PDF]

 

2015

Plaks, V., Boldajipour, B., Linnemann, J.R., Nguyen, N.H., Kersten, K., Wolf, Y., Casbon, A.J., Kong, N., van den Bijgaart, R.J., Sheppard, D., Melton, A.C., Krummel, M.F., Werb, Z. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14;34(5):493-504. doi: 10.1016/j.devcel.2015.07.015. Epub 2015 Aug 27. PMCID: PMC4573906. [PDF]

Hashimoto, M., Yanagisawa, H., Minagawa, S., Sen, D., Ma, R., Murray, L.A., Tsui, P., Lou, J., Marks, J.D., Baron, J.L., Krummel, M.F., Nishimura, S.L. TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 1;195(3):1182-90. doi: 10.4049/jimmunol.1500348. Epub 2015 Jun 24. PMCID: PMC4506848. [PDF]

Hashimoto, M., Yanagisawa, H., Minagawa, S., Sen, D., Goodsell, A., Ma, R., Moermans, C., McKnelly, K.J., Baron, J.L., Krummel, M.F., Nishimura, S.L. A Critical Role for Dendritic Cells in the Evolution of IL-1beta-Mediated Murine Airway Disease. J Immunol. 2015 Apr 15;194(8):3962-9. doi: 10.4049/jimmunol.1403043. Epub 2015 Mar 18. PMCID: PMC4390519. [PDF]

Broz, M.L., Krummel, M.F. The Emerging Understanding of Myeloid Cells as Partners and Targets in Tumor Rejection. Cancer Immunol Res. 2015 Apr;3(4):313-319. PMCID: PMC4391275. [PDF]

Bose, O., Baluk, P., Looney, M.R., Cheng, L.E., McDonald, D.M., Caughey, G.H., Krummel, M.F. Mast Cells Present Protrusions into Blood Vessels upon Tracheal Allergen Challenge in Mice. PLoS One. 2015 Mar 19;10(3):e0118513. doi: 10.1371/journal.pone.0118513. PMCID: PMC4366375. [PDF]

Lindsay, R.S., Corbin, K., Mahne, A., Levitt, B.E., Gebert, M.J., Wigton, E.J., Bradley, B.J., Haskins, K., Jacobelli, J., Tang, Q., Krummel, M.F., Friedman, R.S. Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol. 2015 Jan 15;194(2):522-30. doi: 10.4049/jimmunol.1400626. Epub 2014 Dec 10. PMCID: PMC4282963. [PDF]

 

2014

Mujal, A.M., Krummel, M. The subtle hands of self-reactivity in peripheral T cells. Nat Immunol. 2014 Dec 18;16(1):10-1. doi: 10.1038/ni.3060. PMID: 25521673 [PubMed - in process]. [PDF]

Broz, M.L., Binnewies, M., Boldajipour, B., Nelson, A.E., Pollock, J.L., Erle, D.J., Barczak, A., Rosenblum, M.D., Daud, A., Barber, D.L., Amigorena, S., van’t Veer, L.J., Sperling, A.I., Wolf, D.M., Krummel, M.F. 2014. Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity. Cancer Cell. 2014 Nov 10;26, 1–15. PMCID: PMC4254577. [PDF]

Ortiz-Muñoz, G., Mallavia, B., Bins, A., Headley, M., Krummel, M.F., Looney, M.R. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood. 2014 Aug 20. pii: blood-2014-03-562876. [Epub ahead of print]. PMCID: PMC4208278. [PDF]

Hogan, B.L., Barkauskas, C.E., Chapman, H.A., Epstein, J.A., Jain, R., Hsia, C.C., Niklason, L., Calle, E., Le, A., Randell, S.H., Rock, J., Snitow, M., Krummel, M., Stripp, B.R., Vu, T., White, E.S., Whitsett, J.A., Morrisey, E.E. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 7;15(2):123-38. doi: 10.1016/j.stem.2014.07.012. PMCID: PMC4212493. [PDF]

Gérard, A., Patino-Lopez, G., Beemiller, P., Nambiar, R., Ben-Aissa, K., Liu, Y., Totah, F.J., Tyska, M.J., Shaw, S., Krummel, M.F. Detection of Rare Antigen-Presenting Cells through T Cell-Intrinsic Meandering Motility, Mediated by Myo1g. Cell. 2014 Jul 31;158(3):492-505. DOI: 10.1016/j.cell.2014.05.044. PMCID: PMC4119593. [PDF]

Li, M., Wetzel-Strong, S.E., Hua, X., Tilley, S.L., Oswald, E., Krummel, M.F., Caron, K.M. Deficiency of RAMP1 Attenuates Antigen-Induced Airway Hyperresponsiveness in Mice. PLoS One. 2014 Jul 10;9(7):e102356. doi: 10.1371/journal.pone.0102356. eCollection 2014. PMCID: PMC4092148. [PDF]

Lelkes, E., Headley, M.B., Thornton, E.E., Looney, M.R., Krummel, M.F. The spatiotemporal cellular dynamics of lung immunity. Trends Immunol. 2014 Aug;35(8):379-386. doi: 10.1016/j.it.2014.05.005. Epub 2014 Jun 26. PMCID: PMC4124173. [PDF]

Corbin, K., Pinkard, H., Peck, S., Beemiller, P., Krummel, M.F. Assessing and benchmarking multiphoton microscopes for biologists. Methods Cell Biol. 2014;123:135-51. doi: 10.1016/B978-0-12-420138-5.00008-2. PMID: 24974026 [PubMed - in process]. [PDF]

Friedman, R.S., Lindsay, R.S., Lilly, J.K., Nguyen, V., Sorensen, C.M., Jacobelli, J., Krummel, M.F. An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9223-8. doi: 10.1073/pnas.1322193111. Epub 2014 Jun 10. PMCID: PMC4078867. [PDF]

Patnode, M.L., Bando, J.K., Krummel, M.F., Locksley, R.M., Rosen, S.D. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30;211(7):1281-8. doi: 10.1084/jem.20132336. Epub 2014 Jun 2. PMCID: PMC4076593. [PDF]

Krummel, M.F., Friedman, R.S., Jacobelli, J. Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA. Curr Opin Cell Biol. 2014. 30:9-16. PMID: 24905977. [PDF]

Van Dyken, S.J., Mohapatra, A., Nussbaum, J.C., Molofsky, A.B., Thornton, E.E., Ziegler, S.F., McKenzie, A.N., Krummel, M.F., Liang, H.E., Locksley, R.M. Chitin Activates Parallel Immune Modules that Direct Distinct Inflammatory Responses via Innate Lymphoid Type 2 and γδ T Cells. Immunity. 2014 Mar 20;40(3):414-24. doi: 10.1016/j.immuni.2014.02.003. Epub 2014 Mar 13. PMCID: PMC4019510. [PDF]

 

2013

Beemiller P., Krummel M.F. Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm. Immunol Rev. 2013 Nov;256(1):148-59. doi: 10.1111/imr.12120. PMCID: PMC3831008. [PDF]

Nussbaum, J.C., Van Dyken, S.J., von Moltke, J., Cheng, L.E., Mohapatra, A., Molofsky, A.B., Thornton, E.E., Krummel, M.F., Chawla, A., Liang, H.E., Locksley, R.M. 2013. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10;502(7470):245-248. doi: 10.1038/nature12526. Epub 2013 Sep 15. PMCID: PMC3795960. [PDF]

Jacobelli, J., Matthews, E.M., Chen, S., Krummel, M.F. 2013. Activated T Cell Trans-Endothelial Migration Relies on Myosin-IIA Contractility for Squeezing the Cell Nucleus through Endothelial Cell Barriers. PLoS One. 2013 Sep 19;8(9):e75151. doi: 10.1371/journal.pone.0075151. PMCID: PMC3777879. [PDF]

Gérard, A., Khan, O., Beemiller, P., Oswald, E., Hu, J., Matloubian, M., Krummel, M.F. 2013. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol. 2013 Apr;14(4):356-63. doi: 10.1038/ni.2547. Epub 2013 Mar 10. PMCID: PMC3962671. [PDF]

Gérard, A., Beemiller, P., Friedman, R.S., Jacobelli, J., Krummel, M.F. 2013. Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev. 2013 Jan;251(1):80-96. doi: 10.1111/imr.12021. PMCID: PMC3539221. [PDF]

Cheng, L.E., Hartmann, K., Roers, A., Krummel, M.F., Locksley, R.M. 2013. Perivascular Mast Cells Dynamically Probe Cutaneous Blood Vessels to Capture Immunoglobulin E. Immunity. Jan 24;38(1):166-75. doi: 10.1016/j.immuni.2012.09.022. Epub 2013 Jan 3. PMCID: PMC3576928. [PDF]

 

2012

Zhang, Y., Chen, Y.C., Krummel, M.F., Rosen, S.D. 2012. Autotaxin through Lysophosphatidic Acid Stimulates Polarization, Motility, and Transendothelial Migration of Naive T Cells. J Immunol. 2012 Oct 15;189(8):3914-24. doi: 10.4049/jimmunol.1201604. Epub 2012 Sep 7. PMCID: PMC3509168. [PDF]

Beemiller, P., Jacobelli, J., Krummel, M.F. 2012. Integration of Signaling Microclusters Movement with Cellular Motility in Immunological Synapses. Nature Immunology, Nat Immunol. Jul 1. doi: 10.1038/ni.2364. PMCID: PMC3902181. [PDF].

Thornton, E.E., Krummel, M.F., Looney, M.R. 2012. Live Imaging of the Lung. Curr Protoc Cytom. Apr;Chapter 12:Unit12.28. [PDF]

Thornton, E.E., Looney M.R., Bose, O,. Sen, D., Sheppard, D., Locksley, R., Huang, X., Krummel, M.F. 2012. Spatiotemporally Separated Antigen Uptake by Alveolar Dendritic Cells and Airway Presentation to T Cells in the Lung. J Exp Med., 209(6):1183-99. PMCID: PMC3371730. [PDF]

Engelhardt, J.J., Boldajipour, B., Beemiller, P., Pandurangi, P., Sorensen, C., Werb, Z., Egeblad, M., Krummel, M.F. 2012. Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells. Cancer Cell 21, March 20; 402-417. PMCID: PMC3311997. [PDF]

Gilden, J.K., Peck, S., Chen, Y.C.M., Krummel, M.F. 2012. The septin cytoskeleton facilitates membrane retraction during motility and blebbing. J Cell Biol. Jan 9;196(1):103-14. PMCID: PMC3255977. [PDF]

 

2011

Khan, O., Headley, M., Gerard, A., Wei, W., Liu, L., Krummel, M.F. 2011. Regulation of T Cell Priming by Lymphoid Stroma. PLoS ONE 6(11): e26138. doi:10.1371/journal.pone.0026138. PMCID: PMC3215700. [PDF]

Looney, M.R., Thornton, E.E., Sen, D., Lamm, W.J., Glenny, R.W., Krummel, M.F. 2010. Stabilized imaging of immune surveillance in the mouse lung. Nat Methods. 8(1):91-6. PMCID: PMC3076005. [PDF]

 

2010

Friedman, R.S., Beemiller, P., Sorensen, C.M., Jacobelli, J., Krummel, M.F. 2010. Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med. 11(10):953-61. PMCID: PMC2989766. [PDF]

Katzman S.D., O'Gorman W.E., Villarino A.V., Gallo E., Friedman R.S., Krummel M.F., Nolan G.P., Abbas A.K. 2010 Oct 4. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci. 107(42):18085-90. PMCID: PMC2964228. [PDF]

Beemiller, P., Krummel, M.F. 2010. Mediation of T-Cell Activation by Actin Meshworks. Cold Spring Harb Perspect Biol. 2(9):a002444. PMCID: PMC2926748.

Jacobelli, J., Friedman, R.S., Conti, M.A., Lennon-Dumenil, A.-M., Piel M., Sorensen, C.M., Adelstein, R.S., Krummel, M.F. Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol. 11, 953-961. PMCID: PMC2943564. [PDF]

Krummel, M.F. 2010. Illuminating emergent activity in the immune system by real-time imaging. Nature Immunol. 11(7):554-7. [PDF]

Gilden J., Krummel M.F. 2010. Control of cortical rigidity by the cytoskeleton: Emerging roles for septins. Cytoskeleton (Hoboken). 67(8):477-86. PMCID: PMC2906656. [PDF]

Krummel, M.F., Cahalan, M.D. 2010. The Immunological Synapse: a Dynamic Platform for Local Signaling. J Clin Immunol. 30(3):364-72. PMCID: PMC2874029. [PDF]

Doh, J., Kim, M., Krummel, M.F. 2010. Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions. Biomaterials. Apr;31(12):3422-8. Epub 2010 Feb 1. [PDF]

Doh, J., Krummel, M.F. 2010. Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions. Curr Top Microbiol Immunol. 340:25-50. [PDF]

 

2009

Bullen, A., Friedman, R.S., Krummel, M.F. 2009. Two-photon imaging of the immune system: A custom technology platform for high-speed, multi-color tissue imaging of immune responses. Current Topics in Microbiology and Immunology. 334: 1-29. [PDF]

Melli, K., Friedman, R.S., Finger, E.B., Miao, G. Szot, G.L., Krummel, M.F. and Tang Q. 2009. Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues. J. Immunol. 182: 2590-600. PMCID: PMC3057894. [PDF]

Jacobelli,J., Bennett, F.C., Pandurangi, P. and Krummel, M.F. 2009. Myosin-IIA and ICAM-1 Regulate the Interchange between Two Distinct Modes of T cell Migration J. Immunol. 82: 2041-50. [PDF]

Fife B.T., Eagar T.N., Pauken K.E., Wu J., Obu T., Tang, Q., Azuma M., Krummel, M.F., Bluestone JA. 2009. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal. Nature Immunology. 10(11):1185-92. Epub 2009 Sep 27. PMCID: PMC2778301. [PDF]

Tooley, A.J., Gilden, J., Jacobelli, J., Trimble, W, Kinoshita, M. and Krummel, M.F. 2009. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol. 2009 Jan;11(1):17-26. doi: 10.1038/ncb1808. Epub 2008 Nov 30. PMCID: PMC3777658. [PDF]

2008

Egeblad, M.*, Ewald, A. J.*, Askautrud, H. A., Truitt, M. L., Welm, B. E., Bainbridge, E., Peeters, G., Krummel, M. F., Werb, Z. 2008. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech. 2008 Sep-Oct;1(2-3):155-67; discussion 165. doi: 10.1242/dmm.000596. Epub 2008 Sep 18. PMCID: PMC2562195. [PDF]

Mamchak, A.A., Sullivan,B.M., Hou,B., Lee,L.M., Gilden,J.K., Krummel, M.F. Locksley,R.M, DeFranco,A.L.. 2008. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J.Immunol. 181: 5374-85. PMCID: PMC2657555. [PDF]

Gardner, J.M., DeVoss. J.J., Friedman, R.S., Wong, D.J., Tan, Y.X., Johannes, K.P., Su, M.A. Chang, H.Y., Krummel, M.F., Anderson, M.S. 2008. Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells. Science. 321(5890): 843-7. PMCID: PMC2532844. [PDF]

Sabatos, C.A., Doh, J. Chakravarti, S. Friedman, R.S., Pandurangi, P.G., Tooley, A.J., Krummel, M.F. 2008. A Synaptic Basis for Paracrine Interleukin-2 Signaling in Activating T cells. Immunity. 29(3): 238-248. PMCID: PMC4466225. [PDF]

Beemiller P and Krummel MF. 2008. Distinct functions for HS1 in chemosensory versus adhesive signaling. Nat Immunol. 2008 Aug;9(8):833-4. doi: 10.1038/ni0808-833. [PDF]

Engelhardt J.J., Krummel M.F., 2008. The importance of prolonged binding to antigen-presenting cells for T cell fate decisions. Immunity. 28(2):143-5. [PDF]

 

2007

Krummel, M.F. (2007). Testing the Organization of the Immunological Synapse. Curr Opin Immunol. 19(4):460-2. PMCID: PMC2039889. [PDF]

Krummel, M.F. (2007).  Immunological Synapses: breaking up may be good to do. Cell. 129, 653-655. [PDF]

 

2006

Moldovan MC, Sabbagh L, Breton G, Sekaly RP*and Krummel MF*. (*co-last authors) 2006. Triggering of T cell activation via CD4 dimers. J Immunol. 176(9):5438-45. [PDF]

Krummel M.F. and Macara I. (2006) Maintenance and modulation of T cell polarity. Nature Immunology. 7, 1143-1149. [PDF]

Friedman, R.S. Jacobelli, J, and Krummel, M.F. (2006). Surface-bound chemokines capture and prime T cells for synapse formation. Nature Immunology 7, 1101-8. [PDF]

Tang, Q., Adams, J.Y., Tooley, A.J., Bi, M., Serra, P., Santamaria, P., Krummel, M.F.* and Bluestone, J.A.* (*co-last authors) (2006). Visualizing regulatory T cell control of autoimmune response in NOD diabetic mice. Nature Immunology, 7, 83-92. PMCID: PMC3057888. [PDF]

 

2005

Friedman, R.S., Jacobelli, J., Krummel, M.F. 2005. Mechanisms of T cell Motility and Arrest: Deciphering the Relationship between Intra- and Extracellular determinants. Seminars in Immunology, 17, 387-99. [PDF]

Tooley, A.J., Jacobelli, J., Moldovan, M.C., Douglass, A., and Krummel, M.F. (2005). T cell synapse assembly: proteins, motors and the underlying cell biology. Semin Immunol 17, 65-75. [PDF]

Okada, T. Miller, M.J., Parker, I., Krummel, M.F., O’Garra,A. Cahalan,M.D., Cyster, J.G. (2005). Antigen-engaged B cells undergo directional migration to the T cell zone and form motile conjugates with helper T cells. PLOS Biology 3 1-13. PMCID: PMC1088276. [PDF]

 

2004

Boisvert, J., Edmondson, S. and Krummel, M.F. 2004. Immunological Synapse Formation Licenses CD40-CD40L Accumulations at T-APC Contact Sites. J. Immunol. 173, 3647-3652. [PDF]

Jacobelli, J., Andres, P.G., Boisvert, J., and Krummel, M.F. (2004). New views of the immunological synapse: variations in assembly and function. Curr Opin Immunol 16, 345-352. [PDF]

Jacobelli, J., Chmura, S.A., Buxton, D.B., Davis, M.M., and Krummel, M.F. (2004). A single class II myosin modulates T cell motility and stopping but not synapse assembly. Nature Immunology 5, 531 - 538. [PDF]

Andres, P.G., Howland, K.C., Dresnek, D., Edmondson, S., Abbas, A.K., and Krummel, M.F. (2004). CD28 signals in the immature immunological synapse. J Immunol 172, 5880-5886. [PDF]

 

2002

Richie Ehrlich,L.I., Ebert, P.J.R. Krummel, M.F., Weiss, A. and Davis, M.M. 2002. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity. 17 809-822. [PDF]

Richie, L.I., P.J.R. Ebert, Wu, L.C., Krummel, M.F., Owen, J.J.T., and Davis, M.M. 2002. Imaging synapse formation during thymocyte selection: inability of CD3ζ to form a stable central accumulation during negative selection. Immunity. 16:595-606. [PDF]

Moss, W.C., Irvine, D.J., Davis, M.M., and Krummel, M.F. (2002). Quantifying signaling-induced reorientation of TCRs during immunological synapse formation. Proc Natl Acad Sci U S A 99, 15024-15029. PMCID: PMC137538. [PDF]