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Won-Tak Choi, MD, PhD

Research and Clinical Interests

(1) Flow cytometric measurement of nuclear DNA content abnormalities in Barrett's esophagus, inflammatory bowel disease, gastric dysplasia/adenomas, and other cancer types; (2) Prognostic significance of the CXC chemokine receptor 4 (CXCR4) overexpression in hepatocellular and gastrointestinal tumor progression and metastasis; and (3) liver transplant pathology, including impact of donor liver steatosis on post-transplantation outcomes.

Selected Publications

  • Tsai JH, Rabinovitch PS, Huang D, Small T, Mattis AN, Kakar S, Choi WT. Association of aneuploidy and flat dysplasia with development of high-grade dysplasia or colorectal cancer in patients with inflammatory bowel disease. Gastroenterology. 2017 Dec;153(6):1492-1495.
  • Wen KW, Rabinovitch PS, Huang D, Mattis AN, Lauwers GY, Choi WT. Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia. Mod Pathol. 2018 May; In press.
  • Choi WT, Tsai JH, Rabinovitch PS, Small T, Huang D, Mattis AN, Kakar S. Diagnosis and risk stratification of Barrett's dysplasia by flow cytometric DNA analysis of paraffin-embedded tissue. Gut. 2018 Jun;67:1229-1238.
  • Choi WT, Jen KY, Wang D, Tavakol M, Roberts JP, Gill RM. Donor liver small droplet macrovesicular steatosis is associated with increased risk for recipient allograft rejection. Am J Surg Pathol. 2017 Mar;41(3):365-373.
  • Choi WT, Brown I, Ushiku T, Yozu M, Setia N, Srivastava A, Johncilla M, Pai RK, Gill RM, Fukayama M, Misdraji J, Lauwers GY. Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases. Histopathology. 2018 May;72(6):1007-1014.
  • Choi WT, Wen KW, Rabinovitch PS, Huang D, Mattis AN, Gill RM. DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease-associated serrated epithelial change and traditional serrated adenomas. Histopathology. 2018 May; In press.
  • Choi WT, Ramachandran R, Kakar S. Immunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens. Hum Pathol. 2017 May;63:1-13.
  • Choi WT, Lauwers GY. Patterns of gastric injury: beyond Helicobacter pylori. Surg Pathol Clin. 2017 Dec;10(4):801-822.
  • Choi WT, Emond MJ, Rabinovitch PS, Ahn J, Upton MP, Westerhoff M. "Indefinite for dysplasia" in Barrett's esophagus: inflammation and DNA content abnormality are significant predictors of early detection of neoplasia. Clin Transl Gastroenterol. 2015 Mar 12;6:e81.
  • Choi WT, Rabinovitch PS, Wang D, Westerhoff M. Outcome of "indefinite for dysplasia" in inflammatory bowel disease: correlation with DNA flow cytometry and other risk factors of colorectal cancer. Hum Pathol. 2015 Jul;46(7):939-47.
  • Choi WT, Swanson PE, Grieco VS, Wang D, Westerhoff M. The outcomes of "atypical" and "suspicious" bile duct brushings in the identification of pancreaticobiliary tumors: follow-up analysis of surgical resection specimens. Diagn Cytopathol. 2015 Nov;43(11):885-91.
  • Choi WT, Cherian S, Soma L. Significance of CD10 positive clonal B-cell populations identified by flow cytometry in histologically benign gastric biopsies. J Hematop. 2016. Jun; 9(2): 59-66.
  • Choi WT, Yang Y, Xu Y, An J. Targeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis. Curr Top Med Chem. 2014;14(13):1574-89.

Selected Awards

  • 2011 - Young Investigator Award, 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012)
  • 2008 - Teachers Ranked as Excellent by Their Students (in Human Anatomy), University of Illinois College of Medicine

Additional Information

Won-Tak Choi, MD, PhD
  • Assistant Professor
  • Pathology
  • Division: Anatomic Pathology

Specialty Areas

  • Liver and Gastrointestinal Pathology

Contact Information

  • UCSF
  • Won-Tak Choi, MD, PhD
  • Pathology, Box 0102
  • 505 Parnassus Avenue, Room M-552
  • San Francisco, CA 94143

Hospital Affiliation(s)

  • Moffitt-Long
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