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Stephen Nishimura, MD

Research and Clinical Interests

My clinical interests are centered around pulmonary pathology and administration overseeing the clinical operations of the anatomic pathology division at Zuckerberg General Hospital. My laboratory focuses on the interaction of cells with the extracellular matrix and how that interaction influences cell proliferation, migration and differentiation. We are particularly interested in diseases of extracellular-matrix remodeling of the lung (e.g. airway obstruction in COPD) and mechanisms of tumor immune evasion in lung and other cancers. The cytokine TGF-β is central to both COPD and cancer immune escape. We investigate the role of TGF-β in disease using a variety of approaches including structural biology, cell and molecular biology.

Selected Publications

  • Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks JD, Baron JL, Nishimura SL*, Cheng Y. Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension, Nature Struct Mol Biol, 2018, Aug;25(8):698-704, PMID: 30061598 *Co-corresponding author
  • Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell M, Conrad F, Marks JD, Cheng Y, Baron JL, and Nishimura SL. Integrin αvβ8 expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells, JCI Insight. 2018; 3(20):e122591. https://doi.org/10.1172/jci.insight.122591. PMID: 30333313
  • Minagawa S, Lou J, Seed R, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand O, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak A, Erle D, Reichardt LF, Marks JD, Baron JL, Nishimura SL. Selective targeting of TGF-β activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18;6(241):241ra79. doi: 10.1126/scitranslmed.3008074. PMID: 24944194
  • Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL. TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 1; 195(3):1182-90. PMID: 26109638. PMCID: PMC4506848
  • Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL, Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation and fibrosis, through integrin αvβ8-mediated activation of TGF-β, 2011, J Clin Investigation, Jul 1;121(7):2863-75. PMID: 21646718; PMC3223836

Selected Awards

  • Livingston Trudeau Scholar, American Lung Association

Additional Information

Stephen Nishimura, MD
  • Professor in Residence
  • Pathology
  • Anatomic Pathology

Specialty Area

Pulmonary Pathology

Contact Information

Mailing/Shipping Address:

  • UCSF
  • Stephen Nishimura, MD
  • Pathology, ZSFG Bldg. 3
  • 185 Berry Street, Room 211
  • San Francisco, CA 94143

Other UCSF Organizational Association(s)

BMS

  • UCSF Cancer Center

Hospital Affiliation(s)

  • SF General
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