Matthew Krummel, PhD
Research and Clinical Interests
Our research projects are aimed at understanding the molecular regulation of lymphocyte activation. We use real-time microscopic methods to image the dynamic movement of lymphocyte receptors during antigen recognition. We are also examining cell-cell interactions during immune responses against tumors.
Selected Publications
- Tang, Q, Adams, JY, Tooley, AJ., Bi, M, Serra, P., Santamaria, P, Krummel, MF* and Bluestone, J.A.* (*co-last authors) 2006. Visualizing regulatory T cell control of autoimmune response in NOD diabetic mice. Nature Immunology, 7, 83-92
- Moldovan MC, Sabbagh L, Breton G, Sekaly RP*and Krummel MF*. (*co-last authors) 2006. Triggering of T cell activation via CD4 dimers. J Immunol. 176(9):5438-45.
- Tang, Q and Krummel MF. Imaging the function of regulatory T cells in vivo. Curr Opin Immunol. 2006 Jun 8 (Epub ahead of print)
- Friedman, RS Jacobelli, J, and Krummel, MF 2006. Surface-bound Chemokines Capture and Prime T cells For Synapse Formation. Nature Immunology 7, 1101-8.
- Krummel MF and Macara I. T cell Polarity PARtita: maintenance and modulation of directionality in T lymphocytes Nature Immunology. In press.
Selected Awards
- 2004-2007: Investigator Award, Cancer Research Institute.
- 1997-2000: NRSA Postdoctoral Fellowship, National Institutes of Health.
- 1996-1997: Postdoctoral Fellowship, Juvenile Diabetes Foundation International.
- 1998: PATENT: J.P.Allison, D.R.Leach, and M.F. Krummel. Blockade of T Lymphocyte Down-Regulation Associated with CTLA-4 Signaling. US Patent 5,811,097.
- 1987: Summer Undergraduate Research Fellowship, Howard Hughes Medical Institute.
Additional Information
- Associate Professor
- Pathology
Specialty Area
Immunology
Contact Information
- matthew.krummel@
ucsf.edu - Phone: (415) 514-3130
- Fax: (415) 514-3165
- 513 Parnassus Avenue
- Room HSW-512, Box 0511
- San Francisco, CA 94143-0511