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Jeffry P. Simko, PhD, MD

Research and Clinical Interests

My mission within the Department of Pathology is fourfold. My major focus is genitourinary pathology, where I closely interact with the urologic oncology group of the UCSF Comprehensive Cancer Center concerning clinical and basic science problems. A large number of research projects amenable to resident participation are available in this area. Specific areas include radiologic-pathologic correlation studies and imaging technology development (mainly focused on MRI/MRSI of the prostate and kidney), biomarker discovery efforts, clinical-pathologic correlation studies, and tumor model construction and characterization. These efforts also extend to my participation in some of the cooperative groups performing national clinical trials (NRG and "The Alliance"). I also participate in biospecimen banking efforts here at UCSF, and on a national level through participation in the NRG, one of the NCI-sponsored cooperative groups performing international clinical trials related to cancer treatment. I also perform general surgical pathology sign out and molecular pathology signout duties. I’m currently serving as interim director of the molecular Genetic Pathology Fellowship Program. For additional information, please link to:

Selected Publications (from more than 150)

  • Greenland NY, Zhang L, Cowan JE, Carroll PR, Stohr BA, Simko JP, "Correlation of a Commercial Genomic Risk Classifier with Histologic Patterns in Prostate Cancer," J Urol. 2019 Feb 15 [Epub ahead of print]. PMID: 30810466
  • Behr SC, Aggarwal R, Van Brocklin HF, Flavell RR, Geo K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, Greene KL, Langton-Webster B, Berkman CE, Seo Y, "First-in-Human Phase I study of CTT1057, a Novel 18F Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate Specific Membrane Antigen in Prostate Cancer," J Nucl Med. 2018 Nov 21. pii: jnumed.118.220715. doi: 10.2967/jnumed.118.220715. [Epub ahead of print] PMID: 30464040
  • Leapman MS, Nguyen HG, Cowan JE, Xue L, Stohr B, Simko J, Cooperberg MR, Carroll PR, "Comparing Prognostic Utility of a Single-marker Immunohistochemistry Approach with Commercial Gene Expression Profiling Following Radical Prostatectomy," Eur Urol. 74(5): 668-675 (2018). PMID: 30181067
  • Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B, "Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer," JCI Insight. 3(17) (2018). PMID: 30185663
  • Hicks RM, Simko JP, Westphalen AC, Nguyen HG, Greene KL, Zhang L, Carroll PR, Hope TA, "Diagnostic Accuracy of 68Ga-PSMA-11 PET/MRI Compared with Multiparametric MRI in the Detection of Prostate Cancer," Radiology Sep 18:180788 (2018). [Epub ahead of print] PMID: 30226456
  • Cooperberg MR, Erho N, Chan JM, Feng FY, Fishbane N, Zhao SG, Simko JP, Cowan JE, Lehrer J, Alshalalfa M, Kolisnik T, Chelliserry J, Margrave J, Aranes M, Plessis MD, Buerki C, Tenggara I, Davicioni E, Carroll PR, "The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer," Eur Urol 74(4): 444-452 (2018). PMID: 29853306
  • Lelo A, Prip F, Harris BT, Solomon D, Berry DL, Chaldekas K, Kumar A, Simko J, Jensen JB, Bhattacharyya P, Mannion C, Kim JS, Philips G, Dyrskjøt L, Waldman T, "STAG2 Is a Biomarker for Prediction of Recurrence and Progression in Papillary Non-Muscle-Invasive Bladder Cancer," Clin Cancer Res 24(17): 4145-4153 (2018). PMID: 29954776

Additional Information

Jeffry P. Simko, PhD, MD
  • Professor of Clinical Pathology
  • Departments of Anatomic Pathology, Urology and Radiation Oncology

Specialty Area

Prostate, bladder and kidney tumor surgical pathology and research

Contact Information

Mailing/Shipping Address:

  • UCSF
  • Jeffry P. Simko, PhD, MD
  • Pathology, Box 4066
  • 1825 4th Street, Room M2360
  • San Francisco, CA 94143

Other UCSF Organizational Association(s)

  • Director, Genitourinary Program Tissue Core, UCSF Helen Diller Family Comprehensive Cancer Center
  • Associate Director, RTOG Biospecimen Resource at UCSF (An NCI Sponsored National Cooperative Group Resource)
  • Interim Director, Molecular Genetic Pathology Fellowship Program (ACGME-accredited)
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