UCSF Navigation Bar

UCSF Departments of Pathology & Laboratory Medicine Home Page

Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

Internal Resources

Arie Perry, MD

Research and Clinical Interests

My clinical interests focus most heavily on surgical neuropathology, especially in terms of its application towards neuro-oncology. As a diagnostic neuropathologist with a focus on CNS tumors, I am primarily involved in translational research with the primary goal of developing new diagnostic and prognostic markers, which can be utilized in the clinical management of brain tumor patients. In order to achieve this goal, my lab has applied immunohistochemical, molecular cytogenetic, and genomic screening techniques primarily towards the study of gliomas, meningiomas, and primitive pediatric malignancies. I have been particularly interested in improved classification and grading schemes as well as the identification of molecular genetic markers associated with tumorigenesis, malignant progression, and/or biologic behavior. I collaborate with a number of clinical and scientific researchers both within and outside UCSF and it is our hope that the markers we identify will improve patient management and lead to the development of novel therapeutic approaches. I also maintain a private consultation service for difficult surgical neuropathology cases obtained from the U.S. and abroad, particularly brain tumors.

Selected Publications

  • Perry A, Brat DJ. Perry A, Brat DJ (ed.) Practical Surgical Neuropathology, second edition. Elsevier/Churchill Livingstone, Philadelphia, PA (in press).
  • Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Figarella-Branger D, Perry A, Reifenberger G, von Deimling A (ed.): WHO classification of tumours of the central nervous system (Revised 4th edition). IARC: Lyon 2016.
  • Love S, Ironside J, Budka H, Perry A (ed.). Greenfield’s Neuropathology, 9th Edition. CRC Press, Taylor & Francis Group, LLC, London, UK 2015.
  • Miettinen MM, Antonescu CR, Fletcher CD, Kim A, Lazar AJ, Quezado MM, Reilly KM, Stemmer-Rachamamimov A, Stewart D, Viskochil D, Widemann B, Perry A. Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in neurofibromatosis 1 patients – A consensus overview. Hum Pathol (in press).
  • Solomon DA*, Wood MD*, Tihan T, Bollen AW, Gupta N, Phillips JJ, Perry A. Diffuse midline gliomas with histone H3-K27M mutation: A series of 47 cases assessing the spectrum of morphologic variation and associated genetic alterations. Brain Pathol 26:569-80, 2016.
  • Alexandrescu S*, Korshunov A, Lai SH, Dabiri S, Patil S, Li R, Shih CS, Bonnin JM, Baker JA, Du E, Scharnhorst DW, Samuel D, Ellison DW, Perry A. Epithelioid glioblastomas and anaplastic epithelioid pleomorphic xanthoastrocytomas – same entity or first cousins? Brain Pathol 26:215-223, 2016.
  • Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H, Pekmezci M*, Rice T, Kosel ML, Smirnov IV, Sarkar G, Caron AA, Kollmeyer TM, Praska CE, Chada AR, Halder C, Hansen HM, McCoy LS, Bracci PM, Marshall R, Zheng S, Reis GF*, Pico AR, O’Neill BP, Buckner JC, Giannini C, Huse JT, Perry A, Tihan T, Berger MS, Chang SM, Prados MD, Wiemels J, Wiencke JK, Wrensch MR, Jenkins RB. Glioma groups based on tumor analysis of 1p/19q, IDH, and the TERT promoter. NEJM 372: 2499-508, 2015.
  • Rodriguez FJ, Schniederjan MJ, Nicolaides T, Tihan T, Burger PC, Perry A. High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN). Acta Neuropathol 129: 609-610, 2015.
  • Reis GF*, Pekmezci M*, Hansen HM, Rice T, Marshall RE, Molinaro AM, Phillips JJ, Vogel H, Wiencke JF, Wrensch MR, Walsh KM, Perry A. CDKN2A loss is associated with shortened overall survival in lower grade (WHO II-III) astrocytoma. J Neuropathol Exp Neurol 74: 442-452, 2015.
  • Pekmezci M*, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, Horvai AE, Perry A. Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas. Mod Pathol 28, 187–200, 2015.

Selected Awards

  • 2017-Now: Member of International Collaboration on Cancer Reporting (ICCR) for the development of a reporting protocol for tumours of the central nervous system (CNS).
  • 2016-Now: Member of cIMPACT‑NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy.
  • 2016-Now: Appointed to the Editorial Advisory Board (EAB) for the American Registry of Pathology (ARP) Publications / Armed Forces Institute of Pathology (AFIP) Fascicles.
  • 2016-2017: President of the American Association of Neuropathologists (AANP).
  • 2015-2018: Vice President of International Society of Neuropathology (ISN).
  • 2014: Appointed as Senior Reviewer/Editor for World Health Organization (WHO) 4th edition brain tumor classification scheme update.
  • 2013: Nominated for MS1 Essential Core Teaching Award, UCSF (Medical School Class of 2016).
  • 2008: Professor of the Year Award, Washington University School of Medicine (Medical School Class of 2010).

Additional Information

Arie Perry, MD
  • Professor of Pathology and Neurological Surgery; Director of Neuropathology; Director of Neuropathology Fellowship Training Program
  • Pathology
  • Neuropathology

Specialty Area

  • Surgical Neuropathology

Contact Information

Mailing/Shipping Address:

  • UCSF
  • Arie Perry, MD
  • Pathology, Box 0102
  • 505 Parnassus Avenue, Room M-551
  • San Francisco, CA 94143

Web Site

Educational Links:

Hospital Affiliation(s)

  • UCSF Moffitt-Long Hospital
UCSF home page UCSF home page About UCSF Search UCSF UCSF Medical Center