• Department of Pathology
  • Pathology Staff
• Department of Laboratory Medicine
  • Laboratory Medicine Staff
• Affiliated Hospitals
  • Moffitt-Long
  • Mount Zion Medical Center
  • San Francisco Veterans Affairs Medical Center
  • San Francisco General
• Faculty
  • Pathology
  • Laboratory Medicine

Research and Clinical Interests

My research is focused on immunological tolerance and autoimmunity. Using transgenic and knockout mice, my laboratory is exploring the mechanisms that maintain tolerance to tissue and systemic self-antigens, and the conditions that lead to the breakdown of self-tolerance and the development of autoimmunity. We are also analyzing the roles of different cytokines and T-cell subsets in autoimmune disease, and in the function of regulatory T-cells.

Selected Publications

• Knoechel B, Lohr J, Kahn E, Bluestone JA, and Abbas AK. Sequential development of effector and regulatory T lymphocytes in response to endogenous systemic antigen. J. Exp. Med. 202:1375-1386, 2005.
• Rioux JD, and Abbas AK. Paths to understanding the genetic basis of autoimmune disease. Nature 2005; 435:2-7.
• Sharpe AH, Abbas AK. T-cell costimulation--biology, therapeutic potential, and challenges. New Engl J Med. 355:973-5, 2006.
• Lohr J, Knoechel B, Wang JJ, Villarino AV, and Abbas AK. Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J. Exp. Med. 203:2785-2791, 2006.
• Dooms H, Wolslegel K, Liu P, Abbas AK. Interleukin-2 enhances T cell memory by promoting the generation of IL-7Rα-expressing cells. J. Exp. Med. 204:547-57, 2007.

Books

• Abbas AK, Lichtman AH, Pillai S. CELLULAR AND MOLECULAR IMMUNOLOGY, Philadelphia: Elsevier, 6th edition, 2007. (1st edition published in 1991).
• Abbas AK and Lichtman AH. BASIC IMMUNOLOGY; Functions and Disorders of the Immune System. Elsevier, Philadelphia. 2nd edition, updated 2006. (1st edition published in 2001).
• Kumar V, Abbas AK, Fausto N. ROBBINS & COTRAN PATHOLOGIC BASIS OF DISEASE. Elsevier 7th edition, 2004.
• Kumar V, Abbas AK, Fausto N, Mitchell RN. ROBBINS BASIC PATHOLOGY, Elsevier 8th edition, 2007.

Selected Awards

• 1968 Nuffield Scholar, University of Leeds Medical School, Leeds, England
• 1969 Institute Gold Medal, All-India Institute of Medical Sciences, New Delhi, India
• 1987 Warner-Lambert/Parke-Davis Award, American Association of Pathologists
• 1988 Irving M. London Teaching Award, Harvard-MIT Division of Health Sciences and Technology
• 1994 Harvard Medical School Faculty Prize for Excellence in Teaching, Harvard Medical School
• 1994 -04 NIH MERIT Award, NIH
• 1995 Pre-Clinical Teaching Award, Harvard Medical School
• 2002 Member, Institute of Medicine, National Academy of Sciences
• 2003-04 President, American Society of Investigative Pathology
• 2006 John H. Siegel, MD Distinguished Lecturer, University of Medicine and Dentistry of New Jersey
• 2007 Rous-Whipple Award, American Society of Investigative Pathology

• Professor and Chair
• Pathology

Specialty Area

• Immunology
• Immunopathology

Contact Information

• abul.abbas@ucsf.edu
• Phone: 415-514-0681
• Fax: 415-502-4563

• 505 Parnassus Avenue, Suite M-590
• San Francisco, CA 94143

Other UCSF Organizational Association(s)

Faculty member

• PIBS
• Immunology Graduate Program

Council Member

• Molecular Medicine Program
• Medical Scientist Training Program (MSTP)

Member

• UCSF Cancer Center

Hospital Affiliation(s)

• Moffitt-Long
• Mt. Zion
• Veterans Administration
• SF General