• Department of Pathology
  • Pathology Staff
• Department of Laboratory Medicine
  • Laboratory Medicine Staff
• Affiliated Hospitals
  • Moffitt-Long
  • Mount Zion Medical Center
  • San Francisco Veterans Affairs Medical Center
  • San Francisco General
• Faculty
  • Pathology
  • Laboratory Medicine

Research and Clinical Interests

The Kogan laboratory aims understand the pathogenesis of acute leukemias and to apply this understanding to extend survival for patients with leukemias and other malignancies. Our scientific focus is to comprehend the alterations in cell fate decisions that govern the transformation of normal hematopoietic cells into AML or ALL. We work to identify genetic changes that contribute to leukemia, delineate how genetic changes combine at the cellular and molecular levels to cause transformation and develop improved treatments using molecularly targeted therapeutics. Clinically Dr. Kogan has a strong interest in the biology and medicine of thrombosis and hemostasis.

Selected Publications

• Kuo, YH; Landrette, SF; Heilman, SA; Perrat, PN; Garrett, L; Liu, PP; Le Beau, MM; Kogan, SC; Castilla, LH. Cbfβ-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell, 2006, 9:57-68.
• Sternsdorf, T; Phan, V; Maunakea, ML; Ocampo-Bayuga, C; Sohal, J; Silletto, A; Galimi, F; LeBeau, MM; Evans, RM; Kogan, SC. Forced Retinoic Acid Receptor alpha Homodimers Prime Mice for APL-like Leukemia. Cancer Cell, 2006, 9:81-94.
• Wendel, HG; de Stanchina, E; Cepero, E; Ray, S; Fridman, JS; Emig, M; Veach, DR; Bornmann, WG; Clarkson, B; McCombie, WR; Kogan, SC; Hochhaus, A; Lowe, SW. Loss of p53 impedes the antileukemic response to BCR-ABL inhibition. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103:7444-7449.
• Lee, YJ; Jones, LC; Timchenko, NA; Perrotti, D; Tenen, DG; Kogan, SC. CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but they differ in their anti-leukemic activities. Blood, 2006, 108:2416-2419.
• Forsberg, C; Serwold, T; Kogan, S; Weissman, IL; Passegué, E. New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3(+) multipotent hematopoietic progenitors. Cell, 2006, 126:415-426.

Selected Awards

• 2001 Recipient, Medical Student Teaching Award, Excellence for Small Group Instruction
• 2003 Resident Teaching Award, Department of Laboratory Medicine
• 2004-09 Leukemia & Lymphoma Society Scholar Award

• Associate Professor In Residence Assistant Chief, Clinical Hematology Laboratory Head, Clinical Coagulation Laboratory UCSF Comprehensive Cancer Center, Co-Director, Mouse Pathology Core
• Laboratory Medicine
• Hematology

Specialty Area

• Hematopathology

Contact Information

• Scott.Kogan@ucsf.edu
• Phone: 415-514-1590
• Fax: 415-353-1106

• 513 Parnassus Avenue, Room S-864 Box 0100
• University of California San Francisco
• San Francisco, CA 94143-0100

Web Site

• http://www.ucsf.edu/bms/faculty/kogan.html

Other UCSF Organizational Association(s)

• UCSF Comprehensive Cancer Center, Hematopoietic Malignancies Program
• UCSF Biomedical Sciences Graduate Program

Hospital Affiliation(s)

• UCSF Medical Center
• Mt. Zion
• Moffitt-Long