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Lynn Pulliam MS, PhD

Research and Clinical Interests

My laboratory is interested in neuroinflammation and HIV dementia. We have used HIV seropositive patient monocyte/macrophages (M/M) and gene expression microarrays to develop a phenotype predictive of HIV dementia. Several new proteins discovered from these microarrays have been identified and are being shown to facilitate HIV infection. These gene/proteins have been found to correlate with MRS brain metabolites in recent studies. In addition, the laboratory is looking at HIV with hepatitis C (HCV) coinfection and cognitive impairment. We have identified several gene/biomarkers that correlate with cognitive impairment in coinfected individuals. New studies include looking at monocyte-derived miRNAs within exosomes as facilitators of endothelial and neural cell dysfunction.

Selected Publications

  • Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J and Pulliam L. Peripheral biomarkers do not correlate with cognitive impairment in HAART-treated subjects with HIV-1 infection. J Neurovirol 16:115-24, 2010.
  • Rempel H, Sun B, Calosing C, Pillai S, Pulliam L. Interferon-α drives monocyte gene expression in chronic unsuppressed HIV-1 infection. AIDS 24:1-9, 2010.
  • Pulliam L, Remel H, Sun B, Abadjian L, Calosing C, Meyerhoff DJ. A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in MRS metabolite concentrations. AIDS 25:1721-6, 2011.
  • Sun B, Abadjian L, Rempel H, Monto A, Pulliam L. Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. J Acquir Immune Defic Syndr 62:190-6, 2013.
  • Rempel H, Sun B, Calsoing C, Abadjian L, Monto A, Pulliam L. Monocyte activation in HIV / HCV coinfection correlates with cognitive impairment. PlosOne e55776, 2013.
  • Pulliam L. Cognitive consequences of a sustained monocyte type 1 IFN response in HIV infection. Current HIV Research 12:77-84, 2014.
  • Gupta, A and L. Pulliam. Exosomes as mediators of neuroinflammation. J Neuroinflamm 11: 2014.
  • Pulliam L, Calosing C, Sun B, Grunfeld C, Rempel H. Monocyteactivation from interferon –alpha in HIV infection increases acetylated LDL uptake and ROS production. I Interferon Cyt Res 10:822-828, 2014.

Selected Awards

  • Outstanding Women in Neuroscience Lectureship, ISNV 2009
  • President, International Society for Neurovirology – 2010-2012
  • Professor in Residence, Chief, Microbiology (VAMC)
  • Laboratory Medicine and Medicine
  • Clinical Laboratory

Specialty Area

  • Microbiology

Contact Information

  • Veterans Affairs Medical Center
  • 4150 Clement St., (113A)
  • San Francisco, CA 94121

Hospital Affiliation(s)

  • Veterans Affairs Medical Center
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