Lynn Pulliam MS, PhD
Research and Clinical Interests
My laboratory is interested in neuroinflammation and HIV dementia. We have used HIV seropositive patient monocyte/macrophages (M/M) and gene expression microarrays to develop a phenotype predictive of HIV dementia. Several new proteins discovered from these microarrays have been identified and are being shown to facilitate HIV infection. In addition, the laboratory is looking at HIV infection and aging by studying HIV and its proteins and how they can modulate amyloid beta production in the brain.
Selected Publications
- Kusdra L, McGuire D, and Pulliam L. Changes in monocyte/macrophage neurotoxicity in the era of HAART: implications for HIV-associated dementia. AIDS 15:1-8, 2002.
- Sun, B, Rempel, H, Pulliam, L. Loss of macrophage-secreted lysozyme in HIV-1-associated dementia detected by SELDI mass. AIDS 18:1009-1012, 2004.
- Pulliam L , Sun, B, Rempel, H. Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load. J Neuroimmunol 157:93-98, 2004.
- Rempel, H and L. Pulliam. HIV-1 Tat inhibits neprilysin and elevates amyloid . AIDS 19:127-13, 2005
- Pulliam L, Sun B, Rempel H Martinez PM, Hoekman JD, Rao RJ, Frey II WH and Hanson LR. Intranasaal Tat alters gene expression in the mouse brain. J Neuroimmun Pharm 2006 (in press)
- Professor in Residence, Chief, Microbiology (VAMC)
- Laboratory Medicine
- Clinical Laboratory
Specialty Area
- Microbiology
Contact Information
- Lynn.Pulliam@
ucsf.edu - Phone: 415-221-4810 Ex.2490
- Pager: 517-280-3669
- Fax: 415-831-6574
- Veterans Affairs Medical Center
- 4150 Clement St., (113A)
- San Francisco, CA 94121
Other UCSF Organizational Association(s)
Director of Research
- Veterans Affairs Medical Center (VAMC)
Associate Chief of Staff of Research and Development
- Veterans Affairs Medical Center (VAMC)
Hospital Affiliation(s)
- Veterans Affairs Medical Center