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Laurence J. Marton, MD

Research and Clinical Interests

Polyamines, epigenetics, drug development, genomics, personalized medicine, translational research and medicine

Selected Publications

  • Heiser LM, Sadanandam A, Kuo W-L, Benz SC, Goldstein TC, Ng S, Gibb WJ, Wang NJ, Ziyad S, Tong F, Bayani N, Hu Z, Billig JI, Dueregger A, Lewis S, Jakkula L, Korkola JE, Durinck S, Pepin F, Guan Y, Purdom E, Neuvial P, Bengtsson H, Wood KW, Smith PG, Vassilev L, Hennessy BT, Greshock J, Bachman KE, Hardwicke MA, Park JW, Marton LJ, Wolf DM, Collisson EA, Neve RM, Mills GB, Speed TP, Feiler HS, Wooster RF, Haussler D, Stuart JM, Gray JW, Spellman PT. Subtype and Pathway Specific Responses to Anti-Cancer Compounds in Breast Cancer. PNAS (USA) 109(8):2724-2729, 2012
  • Wu Y, Steinbergs N, Murray-Stewart T, Marton LJ, Casero Jr RA. Oligoamine Analogues in Combination with 2-Difluoromethylornithine (DFMO) Synergistically Induce Re-expression of Aberrantly Silenced Tumor Suppressor Genes. Biochemical J 442(3):693-701, 2012
  • Schenk T, Chen WC, Gollner S, Howell L, Jin L, Hebestreit K, Klein H-U, Popescu AC, Burnett A, Mills K, Casero Jr R, Marton L, Woster P, Minden MD, Dugas M, Wang JCY, Dick JE, Muller-Tidow C, Petrie K, Zelent A. Inhibition of the LSD1/KDM1 Demethylase Reactivates the All-trans-retinoic Acid Differentiation Pathway in Acute Myeloid Leukemia. Nature Medicine 18(4):605-611. doi: 10.1038/nm.2661, 2012
  • Kurata HT, Akrouh A, Li JBW, Marton LJ, Nichols CG. Scanning the Topography of Polyamine Blocker Binding in an Inwardly Rectifying Potassium Channel. J Biol Chem 288:6591-6601, 2013
  • Murray-Stewart T, Hanigan CL, Woster PM, Marton LJ, Casero Jr RA. Histone Deacetylase Inhibition Overcomes Drug Resistance Through a miRNA-Dependent Mechanism. Molecular Cancer Therapeutics 12(10):2088-2099, 2013

Selected Awards

  • Distinguished Alumnus Award, Albert Einstein College of Medicine
  • Honorary Doctorate, Yeshiva University

Present Activities

  • Board of Trustees, American Association for Cancer Research Foundation
  • Board of Directors, Cancer Commons
  • Board of Directors, Bay Area American Committee for the Weizmann Institute of Science
  • Board of Directors, TOMA Bioscience
  • Board of Directors, RenovoRx
  • Board of Directors, Microsonic Systems
  • Board of Directors, Pathologica
  • Chair, Scientific Advisory Board, PharmaJet
  • Medical Advisory Board, Gem Pharmaceuticals
  • Scientific Advisor, Silicom Ventures
  • Advisor, Personalized Medicine World Conference
  • Advisor, Glimpse
  • Adjunct Professor
  • Laboratory Medicine

Contact Information

  • 581 Military Way
  • Palo Alto, CA 94306
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