Frederic Waldman, MD, PhD
Research and Clinical Interests
The research laboratory is focused on exploring the significance of genetic alterations in human malignancies, for application to diagnostic, prognostic, and predictive testing. We are studying progression of solid tumors, based on a model of tumor progression in which tumors are the evolutionary product of an accumulation of genetic events, i.e. mutations, deletions, or amplifications. Each tumor is unique in the events which lead to its development and progression. By studying the pattern of genetic aberrations in actual tumors, we can directly test hypothetical models defining interactions among oncogenes and tumor suppressor genes during tumor progression. Further, we can test the associations of these alterations with clinical outcome and response to gene-based therapies.
Selected Publications
- Hwang ES, DeVries S, Chew KL, Moore DH, 2nd, Kerlikowske K, Thor A, Ljung BM and Waldman FM. Patterns of chromosomal alterations in breast ductal carcinoma in situ. Clin Cancer Res 10(15):5160-7, 2004.
- Mehta KR, Nakao K, Zuraek MB, Ruan DT, Bergsland EK, Venook AP, Fridlyand J, Moore DH, Tokuyasu TA, Jain AN, Warren RS, Terdiman JP and Waldman FM. Fractional genomic alteration detected by array-based comparative genomic hybridization independently predicts survival after hepatic resection for metastatic colorectal cancer. Clinical Cancer Research 11:1791-1797, 2005.
- Blaveri, E., Brewer, J. L., Roydasgupta, R., Fridlyand, J., Devries, S., Koppie, T., Pejavar, S., Mehta, K., Carroll, P., Simko, J. P., and Waldman, F. M. Bladder cancer stage and outcome by array-based comparative genomic hybridization. Clin Cancer Res, 11: 7012-7022, 2005.
- Rini BI, Jaeger E, Weinberg V, Sein N, Chew K, Fong K, Simko J, Small EJ, Waldman FM. Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and Von Hippel-Lindau gene status. BJU Int, July 7, 2006.
- Trautmann K, Terdiman JP, French AJ, Roydasgupta R, Sein N, Kakar S, Fridlyand J, Snijders AM, Albertson D, Thibodeau SN, Waldman FM. Chromosomal Instability in Microsatellite Unstable and Stable Colon Cancer. Clinical Cancer Research. November 1, 2006.
Additional Information
- Professor in Residence, Laboratory Medicine, Urology, and Cancer Center; Co-Director, Molecular Pathology Laboratory; Director, Cancer Center Immunohistochemistry and Molecular Pathology Core
- Laboratory Medicine
Specialty Area
- Molecular Pathology
Contact Information
- waldman@
cc.ucsf.edu - Phone: 415-476-3821
- Fax: 415-476-8218
- UCSF Cancer Center, Box 0808
- San Francisco, CA 94143-0808
Web Site
Hospital Affiliation(s)
- Moffitt-Long