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Arun P. Wiita, MD, PhD

Research and Clinical Interests

My research laboratory is focused on understanding fundamental protein translation as well as chemotherapeutic response in hematologic malignancies. We use a combination of deep sequencing of nucleic acids and mass spectrometry-based proteomics to characterize cellular-wide phenotypes in these diseases.

Selected Publications

  • Wiita, A.P., Ainavarapu, S.R.K., Huang, H.H., and Fernandez, J.M. Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques. Proc. Natl. Acad. Sci. USA 103, 7222-7227 (2006).
  • Wiita, A.P., Perez-Jimenez, R., Walther, K.A., Gräter, F., Berne, B.J., Holmgren, A., Sanchez-Ruiz, J.M., and Fernandez, J.M. Probing the chemistry of thioredoxin catalysis with force. Nature, 150, 124-127 (2007).
  • Ainavarapu, S.R.K., Wiita, A.P., Dougan, L., Uggerud, E., and Fernandez, J.M. Single molecule force spectroscopy measurements of bond elongation during a bimolecular reaction. J. Am. Chem. Soc., 130, 6479-6487 (2008).
  • Perez-Jimenez, R., Wiita, A.P., Larrea-Rodriguez, D., Kosuri, P., Gavira, J.A., Sanchez-Ruiz, J.M., and Fernandez, J.M. Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis. J. Biol. Chem. 283, 27121-27129 (2008).
  • Wiita, A.P., Roubinian, N., Khan, Y., Chin-Hong, P.V., Golden, J.A., and Miller, S. Cytomegalovirus disease and infection in lung transplant recipients in the setting of planned indefinite valganciclovir prophylaxis. Transpl. Infect. Dis. 14, 248-58 (2012). PMID: 22385394.
  • Wiita, A.P., Nambiar A. Longitudinal management with crossmatch-compatible platelets for refractory patients: alloimmunization, response to transfusion, and clinical outcomes. Transfusion 52, 2146-54 (2012).
  • Wiita, A.P., Ziv, E., Wiita, P.J., Urisman, A., Julien, O., Burlingame, A.L., Weissman, J.S., and Wells, J.A. Global cellular response to chemotherapy-induced apoptosis. eLife 02:e01236 (2013).
  • Wiita, A.P., Hsu, G.W., Lu, C.M., Esensten, J., and Wells, J.A. Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Proc. Natl. Acad. Sci. USA 111, 7594-9 (2014).

Selected Awards

  • 2002 Sigma Xi honor society, Princeton U.
  • 2002 Phi Beta Kappa honor society, Princeton U.
  • 2002 Sigma Xi Book Award for undergraduate thesis research, Princeton U.
  • 2008 Winner, Wharton Venture Award, team “Bayesian Diagnosis Pro”, U. Penn.
  • 2008 Dean's Award for Excellence in Research, Columbia U. College of P&S
  • 2012-14 Damon Runyon Cancer Research Foundation Post-doctoral Fellowship
  • 2014-19 NIH-NCI K08 Mentored Clinical Scientist Development Award
  • 2014 Dale Frey Breakthrough Award, Damon Runyon Cancer Research Foundation
Arun P. Wiita, MD, PhD
  • Assistant Professor
  • Laboratory Medicine
  • Division: Cytogenetics Laboratory

Contact Information

Mailing/Shipping Address:

  • UCSF
  • Arun P. Wiita, MD, PhD
  • Laboratory Medicine, Box 0134
  • 185 Berry Street, Suite 290
  • San Francisco, CA 94143

Web Sites

Other UCSF Organizational Association(s)

  • UCSF Cancer Center

Hospital Affiliation(s)

  • Moffitt-Long
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